PERICYCLIC REACTIONS FOR ORGANIC SYNTHESIS
PERICYCLIC REACTIONS FOR ORGANIC SYNTHESIS
批准号:
6179441
负责人:
RICK L DANHEISER
金额:
$23.26万
依托单位国家:
美国
项目类别:
财政年份:
1980
资助国家:
美国
项目状态:
已结题
起止时间:
1980-07-01 至 2002-03-31
中文摘要
本建议着重于周环反应在合成中的应用,
新的方法学的几个重要类别的合成
碳环和杂环有机化合物。
第一部分介绍了新的战略发展的综合
五元和六元芳族、杂芳族和
二氢芳族体系。 分子内[4+2]环加成
结合酶的反应将被研究和应用于
高浓缩多环系统的新途径。 杂环
该过程的变体将被开发,以取代
吡啶、二氢异苯并呋喃和异吲哚。 的应用
本化学合成的五环聚酮海洋
具有蛋白酪氨酸激酶抑制活性的天然产物,
抗病毒药物假鹰爪碱B(mappicine)的合成
酮)也将进行检查。
提案的第二部分描述了串联的应用
炔丙基排斥-不对称反电子需求
分子内乙烯基丙二烯Diels-Alder策略
一种全综合的简明方法
刺激剂甘氨菌素A。
提案的第三部分介绍了一种新方法的发展
用于合成(三烷基甲硅烷基)乙烯基和炔基烯酮,
这些化合物在新的环加成方法中的应用
导致五元和六元碳环和杂环
化合物.
英文摘要
This proposal focuses on the application of pericyclic reactions in
new methodology for the synthesis of several important classes of
carbocyclic and heterocyclic organic compounds.
Part I describes the development of new strategies for the synthesis
of five- and six- membered aromatic, heteroaromatic, and
dihydroaromatic systems. Intramolecular [4+2] cycloaddition
reactions of conjugated enzymes will be investigated and employed in
new routes to highly condensed polycyclic systems. Heterocyclic
variants of this process will be developed leading to substituted
pyridines, dihydroisobenzofurans, and isoindoles. The application of
this chemistry to the synthesis of pentacylic polyketide marine
natural products with protein tyrosine kinase inhibitory activity and
to the synthesis of the antiviral agent nothapodytine B (mappicine
ketone) will also be examined.
Part II of the proposal describes the application of a tandem
propargylic rearrangement-asymmetric inverse electron-demand
intramolecular vinylallene Diels-Alder strategy in an exceptionally
concise approach to the total synthesis of the nematod hatching
stimulus agent glycinoeclepin A.
Part III of the proposal describes the development of a new method
for the synthesis of (trialkylsilyl) vinyl- and alkynylketens and
application of these compounds in new cycloadditions processes
leading to five- and six-membered carbocyclic and heterocyclic
compounds.
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Pericyclic Reactions for Organic Synthesis
-
批准号:7392842
-
项目类别:
-
资助金额:$29.91万
-
财政年份:1980
-
负责人:RICK L DANHEISER
-
依托单位:
PERICYCLIC REACTIONS FOR ORGANIC SYNTHESIS
-
批准号:6881195
-
项目类别:
-
资助金额:$29.01万
-
财政年份:1980
-
负责人:RICK L DANHEISER
-
依托单位:
Pericyclic Reactions for Organic Synthesis
-
批准号:7583877
-
项目类别:
-
资助金额:$29.76万
-
财政年份:1980
-
负责人:RICK L DANHEISER
-
依托单位:
PERICYCLIC REACTIONS FOR ORGANIC SYNTHESIS
-
批准号:2175145
-
项目类别:
-
资助金额:$21.54万
-
财政年份:1980
-
负责人:RICK L DANHEISER
-
依托单位:
PERICYCLIC REACTIONS FOR ORGANIC SYNTHESIS
-
批准号:6475198
-
项目类别:
-
资助金额:$31.58万
-
财政年份:1980
-
负责人:RICK L DANHEISER
-
依托单位:
PERICYCLIC REACTIONS FOR ORGANIC SYNTHESIS
-
批准号:3275562
-
项目类别:
-
资助金额:$12.42万
-
财政年份:1980
-
负责人:RICK L DANHEISER
-
依托单位:
PERICYCLIC REACTIONS FOR ORGANIC SYNTHESIS
-
批准号:3275564
-
项目类别:
-
资助金额:$19.37万
-
财政年份:1980
-
负责人:RICK L DANHEISER
-
依托单位:
PERICYCLIC REACTIONS FOR ORGANIC SYNTHESIS
-
批准号:3275569
-
项目类别:
-
资助金额:$18.74万
-
财政年份:1980
-
负责人:RICK L DANHEISER
-
依托单位:
Pericyclic Reactions for Organic Synthesis
-
批准号:7196759
-
项目类别:
-
资助金额:$30.06万
-
财政年份:1980
-
负责人:RICK L DANHEISER
-
依托单位:
PERICYCLIC REACTIONS FOR ORGANIC SYNTHESIS
-
批准号:3275570
-
项目类别:
-
资助金额:$19.76万
-
财政年份:1980
-
负责人:RICK L DANHEISER
-
依托单位:
PERICYCLIC REACTIONS FOR ORGANIC SYNTHESIS
-
批准号:3275567
-
项目类别:
-
资助金额:$15.41万
-
财政年份:1980
-
负责人:RICK L DANHEISER
-
依托单位:
PERICYCLIC REACTIONS FOR ORGANIC SYNTHESIS
-
批准号:6385390
-
项目类别:
-
资助金额:$23.94万
-
财政年份:1980
-
负责人:RICK L DANHEISER
-
依托单位:
PERICYCLIC REACTIONS FOR ORGANIC SYNTHESIS
-
批准号:2391883
-
项目类别:
-
资助金额:$22.38万
-
财政年份:1980
-
负责人:RICK L DANHEISER
-
依托单位:
PERICYCLIC REACTIONS FOR ORGANIC SYNTHESIS
-
批准号:3275565
-
项目类别:
-
资助金额:$13.55万
-
财政年份:1980
-
负责人:RICK L DANHEISER
-
依托单位:
Pericyclic Reactions for Organic Synthesis
-
批准号:7778924
-
项目类别:
-
资助金额:$29.3万
-
财政年份:1980
-
负责人:RICK L DANHEISER
-
依托单位:
PERICYCLIC REACTIONS FOR ORGANIC SYNTHESIS
-
批准号:6726770
-
项目类别:
-
资助金额:$29.08万
-
财政年份:1980
-
负责人:RICK L DANHEISER
-
依托单位:
PERICYCLIC REACTIONS FOR ORGANIC SYNTHESIS
-
批准号:3275566
-
项目类别:
-
资助金额:$14.46万
-
财政年份:1980
-
负责人:RICK L DANHEISER
-
依托单位:
PERICYCLIC REACTIONS FOR ORGANIC SYNTHESIS
-
批准号:3275568
-
项目类别:
-
资助金额:$15.47万
-
财政年份:1980
-
负责人:RICK L DANHEISER
-
依托单位:
PERICYCLIC REACTIONS FOR ORGANIC SYNTHESIS
-
批准号:6624455
-
项目类别:
-
资助金额:$29.16万
-
财政年份:1980
-
负责人:RICK L DANHEISER
-
依托单位:
PERICYCLIC REACTIONS FOR ORGANIC SYNTHESIS
-
批准号:2175144
-
项目类别:
-
资助金额:$23.01万
-
财政年份:1980
-
负责人:RICK L DANHEISER
-
依托单位:
海外基金