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PERICYCLIC REACTIONS FOR ORGANIC SYNTHESIS

PERICYCLIC REACTIONS FOR ORGANIC SYNTHESIS
有机合成的周环反应
批准号:
6179441
负责人:
RICK L DANHEISER
金额:
$23.26万
依托单位国家:
美国
项目类别:
财政年份:
1980
资助国家:
美国
项目状态:
已结题
起止时间:
1980-07-01 至 2002-03-31

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中文摘要
翻译
本提案着重于周环反应在
英文摘要
This proposal focuses on the application of pericyclic reactions in new methodology for the synthesis of several important classes of carbocyclic and heterocyclic organic compounds. Part I describes the development of new strategies for the synthesis of five- and six- membered aromatic, heteroaromatic, and dihydroaromatic systems. Intramolecular [4+2] cycloaddition reactions of conjugated enzymes will be investigated and employed in new routes to highly condensed polycyclic systems. Heterocyclic variants of this process will be developed leading to substituted pyridines, dihydroisobenzofurans, and isoindoles. The application of this chemistry to the synthesis of pentacylic polyketide marine natural products with protein tyrosine kinase inhibitory activity and to the synthesis of the antiviral agent nothapodytine B (mappicine ketone) will also be examined. Part II of the proposal describes the application of a tandem propargylic rearrangement-asymmetric inverse electron-demand intramolecular vinylallene Diels-Alder strategy in an exceptionally concise approach to the total synthesis of the nematod hatching stimulus agent glycinoeclepin A. Part III of the proposal describes the development of a new method for the synthesis of (trialkylsilyl) vinyl- and alkynylketens and application of these compounds in new cycloadditions processes leading to five- and six-membered carbocyclic and heterocyclic compounds.
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Pericyclic Reactions for Organic Synthesis
PERICYCLIC REACTIONS FOR ORGANIC SYNTHESIS
Pericyclic Reactions for Organic Synthesis
PERICYCLIC REACTIONS FOR ORGANIC SYNTHESIS
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