PERICYCLIC REACTIONS FOR ORGANIC SYNTHESIS

有机合成的周环反应

• 批准号: 3275562
• 负责人: RICK L DANHEISER
• 金额: $ 12.42万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-07-01 至 1990-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3275562
• 关键词: anthracyclines; antifungal antibiotics; antiviral agents; carbonyl group; chemical synthesis; cyclic compound; cyclization; cyclopropanes; drug design /synthesis /production; ketene; ketones; phenols; sesquiterpenes; stereochemistry

This proposal focuses on the application of pericyclic reactions in new methodology for the synthesis of several important classes of organic compounds. General, stereocontrolled routes to functionalized cyclopropane derivatives will be developed based on the chemistry of cyclopropylboranes. Anion-accelered [1,3] sigmatropic rearrangements will be employed in stereocontrolled annulation approaches to five-membered carbocyclic compounds. A regiocontrolled annulation route to highly substituted aromatic compounds will be developed and applied to the total synthesis of the biologically important natural products bhogatin, ascochlorin, cristatin, barbatusol, and mycophenolic acid

本文主要介绍了周环反应在新合成中的应用 几类重要有机化合物的合成方法 化合物. 官能化环丙烷衍生物的一般立体控制路线 将在环丙基硼烷的化学基础上开发。 阴离子加速的[1，3] σ迁移重排将被用于 五元碳环的立体控制成环方法 化合物. 高取代芳香族化合物的区域控制成环反应 将被开发并应用于生物全合成 重要的天然产物bhogatin，ascochlorin，cristatin，barbatusol， 和霉酚酸