NEW EXPOXIDATION REAGENTS

新的氧化试剂

• 批准号: 3275167
• 负责人: JULIUS REBEK
• 金额: $ 9.07万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-04-01 至 1987-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3275167
• 关键词: chemical synthesis; cis trans isomerization; cyclic compound; drug design /synthesis /production; drug interactions; epoxides; oxidation; peroxides; reagent /indicator

A new peracid reagent is described for the selective epoxidation of olefins. This reagent is the first system to show selectivity between cis and trans olefins and research is proposed to develop it into a reagent capable of asymmetric epoxidation. Other hydroperoxides imbedded in a chiral or hindered environment are also proposed including Alpha-hydroperoxy ethers and peracids with geometries altered by intramolecular hydrogen bonds. The ultimate goal is to provide organic synthesis with reagents of enzyme-like selectivity. These reagents could open new strategies for the synthesis of highly-oxygenated natural products such as macrolides and carbohydrates.

介绍了一种新的过酸试剂，用于选择性环氧化