Cell facilitated controlled radical polymerisation

细胞促进受控自由基聚合

• 批准号: DP170104321
• 负责人: Prof Greg Qiao
• 金额: $ 30.16万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170104321
• 关键词: Cell; facilitated; controlled; radical; polymerisation

This project aims to develop a controlled polymerisation method by combining reversible addition fragmentation chain (RAFT) polymerisation technology and the redox processes within bacterial cells. This polymerisation method will copy biological information in the bacterial cell surface into a growing polymer structure. Variations in the monomer structures and functionality will be used to control the incorporation of cell surface chemistry into the new polymer structure. Such cell-enabled controlled polymerisation could advance polymer synthesis resulting in biologically instructed polymer-mimics and new antibacterial agents.

该项目旨在通过结合可逆加成碎片链（RAFT）聚合技术和细菌细胞内的氧化还原过程，开发一种可控的聚合方法。这种聚合方法将细菌细胞表面的生物信息复制到生长的聚合物结构中。单体结构和功能的变化将用于控制细胞表面化学与新聚合物结构的结合。这种细胞激活的控制聚合可以促进聚合物的合成，从而产生生物指示的聚合物模拟物和新的抗菌剂。