Engineering drug transportation behaviour in polymeric gel systems

工程聚合物凝胶系统中的药物运输行为

• 批准号: LP150100315
• 负责人: Prof Greg Qiao
• 金额: $ 21.92万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-08-31 至 2020-08-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP150100315
• 关键词: Engineering; drug; transportation; behaviour; polymeric

In collaboration with Seagull Technologies, this project aims to engineer, study and mathematically model ultrasound-assisted biomacromolecule transport behaviour within polymeric gel systems, which may be useful in new drug delivery methods. The intended outcome is a novel set of polymeric gel systems, which can reversibly bind a wide variety of drugs (small molecules, nucleic acid based drugs, proteins), in which drug release is triggered by an electric potential and drug transport is controlled by means of sonophoresis. The main advantage of drug delivery via sonophoresis is elimination of risks associated with injections such as infection and damage to local tissue, and elimination of patient discomfort, pain and fear.

该项目与海鸥技术公司合作，旨在设计、研究和数学建模聚合物凝胶系统内的超声辅助生物大分子运输行为，这可能有助于新的药物递送方法。预期的结果是一组新的聚合物凝胶系统，其可以可逆地结合多种药物（小分子、基于核酸的药物、蛋白质），其中药物释放由电势触发，并且药物转运通过超声促渗控制。通过超声促渗法给药的主要优点是消除了与注射相关的风险，如感染和局部组织损伤，并消除了患者的不适、疼痛和恐惧。