Peptide-based Star Polymers for Improved Biointeraction and Targeted Anticancer Therapies

基于肽的星形聚合物可改善生物相互作用和靶向抗癌治疗

• 批准号: DP140100002
• 负责人: Prof Greg Qiao
• 金额: $ 40.63万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140100002
• 关键词: Peptide; based; Star; Polymers; Improved

The aim of this project is to develop peptide-based star polymer nanocarriers for targeted drug delivery to cancer stem cells which integrate aptamer targeting technology and biointeraction studies with blood plasma fluid. The significance of this research is it pioneers the development of a drug delivery system that minimises plasma opsonization through understanding polymer-plasma interactions, which in turn increases tumour specificity and cell internalisation through incorporation of targeting aptamers and triggered drug release. This project will use rational design, advanced macromolecular engineering and an interdisciplinary collaboration to generate next-generation polymer therapeutics for drug delivery.

本项目的目的是开发基于肽的星星聚合物纳米载体，用于靶向癌症干细胞的药物递送，其整合了适体靶向技术和与血浆流体的生物相互作用研究。这项研究的意义在于它开创了一种药物递送系统的发展，该系统通过理解聚合物-血浆相互作用来最大限度地减少血浆调理作用，从而通过引入靶向适体和触发药物释放来增加肿瘤特异性和细胞内化。该项目将使用合理的设计，先进的大分子工程和跨学科的合作，以产生下一代聚合物治疗药物输送。