NEW EXPOXIDATION REAGENTS

新的氧化试剂

• 批准号: 3275168
• 负责人: JULIUS REBEK
• 金额: $ 8.62万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-04-01 至 1987-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3275168
• 关键词: chemical synthesis; cis trans isomerization; cyclic compound; drug design /synthesis /production; drug interactions; epoxides; oxidation; peroxides; reagent /indicator

A new peracid reagent is described for the selective epoxidation of olefins. This reagent is the first system to show selectivity between cis and trans olefins and research is proposed to develop it into a reagent capable of asymmetric epoxidation. Other hydroperoxides imbedded in a chiral or hindered environment are also proposed including Alpha-hydroperoxy ethers and peracids with geometries altered by intramolecular hydrogen bonds. The ultimate goal is to provide organic synthesis with reagents of enzyme-like selectivity. These reagents could open new strategies for the synthesis of highly-oxygenated natural products such as macrolides and carbohydrates.

本文报道了一种新的过酸试剂， 烯烃。 该试剂是第一个在顺式和反式之间显示出选择性的体系。 和反式烯烃，并建议研究将其开发为试剂 能够不对称环氧化。 其他氢过氧化物， 还提出了手性或受阻环境，包括 具有通过以下改变的几何形状的α-氢过氧醚和过酸： 分子内氢键 最终目标是提供有机 用类酶选择性试剂合成。 这些试剂可以 为高含氧天然产物的合成开辟了新的策略 如大环内酯类和碳水化合物。