SYNTHESIS OF CC-1065 AND OTHER COMPLEX HETEROCYCLES

CC-1065 和其他复杂杂环的合成

• 批准号: 3281796
• 负责人: PHILIP D MAGNUS
• 金额: $ 6.37万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-07-01 至 1988-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3281796
• 关键词: antineoplastics; chemical structure function; drug design /synthesis /production; drug screening /evaluation; indoles; pyrroles

The completion of the total synthesis of the antitumor agent CC-1065 is described; and plans to probe new and hopefully less toxic analogs are outlined. The key steps are the coupling of the A-portion to the B-portion to give an AB-analog, and its subsequent coupling to a B-portion to make CC-1065. A total synthesis of the complex alkaloid strychnine is described. Analogs of strychnine are potential gastric stimulators. The last section describes a proposed total synthesis of koumine using trans-annular vinylogous Pummerer chemistry.

抗肿瘤剂CC-1065的全合成完成， 描述;并计划探索新的，希望毒性较小的类似物， 概述。 关键步骤是A部分与B部分的耦合 以得到AB-类似物，并将其随后偶联到B-部分， CC-1065 本文报道了复杂生物碱士的宁的全合成。 类似物 士的宁是潜在的胃刺激剂。 最后一部分描述了一个建议的全合成钩吻素， 跨环乙烯基聚合物Pummerer化学