21EBTA. Bioengineering iLUNGs - Building scalable, integrated, multicellular and personalised human in vitro LUNGs

21 EBTA。

基本信息

  • 批准号:
    BB/W014564/1
  • 负责人:
  • 金额:
    $ 166.61万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2022
  • 资助国家:
    英国
  • 起止时间:
    2022 至 无数据
  • 项目状态:
    未结题

项目摘要

The human respiratory system exists to perform gas exchange and thus support life. The entire cellular surface of the lung is continuous with air from the main airways, to tree-like branched airways and the sacs where gas exchange happens - these are called alveoli. Although there has been great progress in laboratory models of individual parts of the lung, they do not have this feature of functional evolution from the airways to the the alveoli. The absence of integrated models has hampered progress in understanding lung physiology and what happens in lung disease. Further, key societal issues like the development of new inhaled treatments for specific diseases and an understanding of what environmental pollution does to the lung would be really enhanced by better models. In this project, we aim to engineer a living model of the human lung where the airway to the alveolar sacs are fully connected and functional. We call it the iLUNG. A key advantage of our work is that we will use multiple cell types from an individual patient to create them. This means that they will be truly individualised "mini-lungs" and will therefore hopefully reflect the disease associated with the person that we grew the cells from. This opens up the possibility of more targeted treatments for lung disease as well new possibilities to understand basic lung biology and how different types of cells in the lung talk to each other.We have put together a great team of lung bioengineers for this proposal and have the engineering and scientific infrastructure as well as access to patients to make this project deliverable. We are tremendously excited by the potential of the iLUNG and are fully motivated to train the next generation of lung bioengineers. Finally we are clear that we want this technology to be used widely in academia and industry and eventually be both a scientific and commercial success.
人类呼吸系统的存在是为了进行气体交换,从而维持生命。肺的整个细胞表面是连续的,空气从主气道,到树状分支气道和气体交换发生的囊-这些被称为肺泡。虽然肺的各个部分的实验室模型已经取得了很大的进展,但它们不具有从气道到肺泡的功能演变的特征。缺乏综合模型阻碍了对肺部生理学和肺部疾病发生情况的理解。此外,更好的模型将真正增强关键的社会问题,如针对特定疾病的新吸入治疗方法的开发以及对环境污染对肺部影响的理解。在这个项目中,我们的目标是设计一个人肺的活体模型,其中气道到肺泡囊是完全连接和功能的。我们称之为肺。我们工作的一个关键优势是,我们将使用来自单个患者的多种细胞类型来创建它们。这意味着它们将是真正个性化的“迷你肺”,因此有望反映与我们从中培养细胞的人相关的疾病。这为更有针对性的肺部疾病治疗开辟了可能性,也为了解基本的肺部生物学以及肺部不同类型的细胞如何相互交流提供了新的可能性。我们为这个项目组建了一支优秀的肺部生物工程师团队,拥有工程和科学基础设施以及接触患者的机会,使这个项目能够交付使用。我们对iLUNG的潜力感到非常兴奋,并完全有动力培养下一代肺部生物工程师。最后,我们很清楚,我们希望这项技术在学术界和工业界得到广泛应用,并最终在科学和商业上取得成功。

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Biointerface Fiber Technology from Electrospinning to Inflight Printing.
  • DOI:
    10.1021/acsami.3c10617
  • 发表时间:
    2023-12
  • 期刊:
  • 影响因子:
    9.5
  • 作者:
    Wenyu Wang;Stanley Gong Sheng Ka;Yifei Pan;Yaqi Sheng;Yan Yan Shery Huang-Yan
  • 通讯作者:
    Wenyu Wang;Stanley Gong Sheng Ka;Yifei Pan;Yaqi Sheng;Yan Yan Shery Huang-Yan
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Frank McCaughan其他文献

Deregulated SOX2 drives dysplasia in a novel 3D organotypic model of bronchial dysplasia
  • DOI:
    10.1016/j.jtho.2015.12.033
  • 发表时间:
    2016-02-01
  • 期刊:
  • 影响因子:
  • 作者:
    Lúcia L. Correia;Trevor D. Littlewood;Gerard Evan;Frank McCaughan
  • 通讯作者:
    Frank McCaughan
5 - Impact of the New Optimal Lung Cancer Pathway (NOLCP) at Cambridge University Hospitals (CUH) NHS Trust
5 - 剑桥大学医院(CUH)NHS 信托的新最佳肺癌路径(NOLCP)的影响
  • DOI:
    10.1016/s0169-5002(23)00432-4
  • 发表时间:
    2023-04-01
  • 期刊:
  • 影响因子:
    4.400
  • 作者:
    Laura Gordon;Jake Beckford;Tiago Verissimo;Hilary Roberts;Judith Babar;Frank McCaughan
  • 通讯作者:
    Frank McCaughan
In vitro platform to model the function of ionocytes in the human airway epithelium
模拟人气道上皮离子细胞功能的体外平台
  • DOI:
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    5.8
  • 作者:
    Marta Vilà;L. Pinte;Ricardo Fradique;Erika Causa;Heleen M. Kool;Mayuree Rodrat;C. Morell;Maha Al;Linsey Porter;Wenrui Guo;R. Maeshima;Stephen L. Hart;Frank McCaughan;A. Granata;David N Sheppard;R. A. Floto;E.L. Rawlins;P. Cicuta;Ludovic Vallier
  • 通讯作者:
    Ludovic Vallier
16 Establishing the impact of dedicated MDT and alert system for the management of pulmonary nodules in a tertiary referral centre
16. 在三级转诊中心建立专门的多学科团队(MDT)和警报系统对肺结节管理的影响
  • DOI:
    10.1016/j.lungcan.2025.108127
  • 发表时间:
    2025-02-01
  • 期刊:
  • 影响因子:
    4.400
  • 作者:
    James Nathan;Frank McCaughan;Theresia A Mikolasch;Tiago Verissimo;Marusa Kotnik;Jonathan Knight
  • 通讯作者:
    Jonathan Knight

Frank McCaughan的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Frank McCaughan', 18)}}的其他基金

A novel murine model of squamous lung cancer
一种新型的鳞状肺癌小鼠模型
  • 批准号:
    NC/S001204/1
  • 财政年份:
    2018
  • 资助金额:
    $ 166.61万
  • 项目类别:
    Research Grant

相似海外基金

Investigating bioengineering approaches to produce immuno-modulatory mesenchymal stromal cells and their extracellular vesicle
研究生产免疫调节间充质基质细胞及其细胞外囊泡的生物工程方法
  • 批准号:
    2608627
  • 财政年份:
    2025
  • 资助金额:
    $ 166.61万
  • 项目类别:
    Studentship
NSF PRFB FY23: Effects of bioengineering on community assembly and ecosystem functioning in a soil microbial community
NSF PRFB FY23:生物工程对土壤微生物群落的群落组装和生态系统功能的影响
  • 批准号:
    2305961
  • 财政年份:
    2024
  • 资助金额:
    $ 166.61万
  • 项目类别:
    Fellowship Award
Sensory and bioengineering approaches to predict hearing abilities in fish
预测鱼类听力的感官和生物工程方法
  • 批准号:
    DE240100188
  • 财政年份:
    2024
  • 资助金额:
    $ 166.61万
  • 项目类别:
    Discovery Early Career Researcher Award
2024 Summer Biomechanics, Bioengineering, and Biotransport Conference; Lake Geneva, Wisconsin; 11-14 June 2024
2024年夏季生物力学、生物工程和生物运输会议;
  • 批准号:
    2413182
  • 财政年份:
    2024
  • 资助金额:
    $ 166.61万
  • 项目类别:
    Standard Grant
Can we heal people using electricity? Developing fundamental understanding and bioelectronic devices to exploit bioelectricity in bioengineering.
我们可以用电来治愈人们吗?
  • 批准号:
    MR/X032159/1
  • 财政年份:
    2024
  • 资助金额:
    $ 166.61万
  • 项目类别:
    Fellowship
Conference: The 50th Northeast Bioengineering Conference
会议:第50届东北生物工程会议
  • 批准号:
    2412513
  • 财政年份:
    2024
  • 资助金额:
    $ 166.61万
  • 项目类别:
    Standard Grant
SBIR Phase I: Bioengineering probiotic yeast to mitigate methane emissions from cattle
SBIR 第一阶段:生物工程益生菌酵母可减少牛的甲烷排放
  • 批准号:
    2322126
  • 财政年份:
    2024
  • 资助金额:
    $ 166.61万
  • 项目类别:
    Standard Grant
Bioengineering technologies for harvesting rare earth elements from waste
从废物中回收稀土元素的生物工程技术
  • 批准号:
    IM240100006
  • 财政年份:
    2024
  • 资助金额:
    $ 166.61万
  • 项目类别:
    Mid-Career Industry Fellowships
Study on magnetization dynamics of magnetic beads for advanced bioengineering
先进生物工程磁珠磁化动力学研究
  • 批准号:
    23K17750
  • 财政年份:
    2023
  • 资助金额:
    $ 166.61万
  • 项目类别:
    Grant-in-Aid for Challenging Research (Exploratory)
Semiconductor Biomaterials to Speed Bone Healing: A Bioengineering-Driven Approach
半导体生物材料加速骨骼愈合:生物工程驱动的方法
  • 批准号:
    10587508
  • 财政年份:
    2023
  • 资助金额:
    $ 166.61万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了