REGULATION OF EUKARYOTIC GENE EXPRESSION
REGULATION OF EUKARYOTIC GENE EXPRESSION
批准号:
3280006
负责人:
CHARLES B LAWRENCE
金额:
$9.55万
依托单位国家:
美国
项目类别:
财政年份:
1984
资助国家:
美国
项目状态:
已结题
起止时间:
1984-09-26 至 1987-08-31
中文摘要
来自许多调查线索的证据表明,
真核生物mRNA 5英尺末端的序列在决定
翻译开始的效率。 我们建议
在体外系统地突变特定5型腺病毒的基因
mRNA,将突变基因重新整合到病毒基因组中,然后测量
各种突变对翻译效率的影响
使用本实验室开发的体内测定法检测突变mRNA。
这种方法将定义mRNA 5英尺末端的序列
这是决定翻译效率的重要因素,
生理条件。
英文摘要
Evidence from many lines of investigation suggest a complex role for the
sequences at the 5 feet-terminus of eukaryotic mRNAs in determining the
efficiency with which translation is initiated. We propose to
systematically mutate in vitro the gene for a specific adenovirus type 5
mRNA, reincorporate the mutated gene into the viral genome and then measure
the effect of the various mutations on the efficiency of translation of the
mutated mRNA using an in vivo assay which has been developed in this lab.
This approach will define the sequences at the 5 feet-terminus of mRNAs
which are important in determining the efficiency of translation under
physiological conditions.
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HICSS-26 CONFERENCE--MINITRACK ON GENOME INFORMATICS
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批准号:3435541
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项目类别:
-
资助金额:$1.22万
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财政年份:1992
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负责人:CHARLES B LAWRENCE
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依托单位:
MOLECULAR BIOLOGY INFORMATION RESOURCE
-
批准号:3450367
-
项目类别:
-
资助金额:$18.54万
-
财政年份:1991
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负责人:CHARLES B LAWRENCE
-
依托单位:
MOLECULAR BIOLOGY INFORMATION RESOURCE
-
批准号:3450365
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项目类别:
-
资助金额:$34.63万
-
财政年份:1991
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负责人:CHARLES B LAWRENCE
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依托单位:
MOLECULAR BIOLOGY RESEARCH SUPPORT SYSTEM
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批准号:3519165
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项目类别:
-
资助金额:$19.35万
-
财政年份:1985
-
负责人:CHARLES B LAWRENCE
-
依托单位:
MOLECULAR BIOLOGY INFORMATION RESOURCE
-
批准号:3450640
-
项目类别:
-
资助金额:$19.98万
-
财政年份:1985
-
负责人:CHARLES B LAWRENCE
-
依托单位:
MOLECULAR BIOLOGY INFORMATION RESOURCE
-
批准号:3450638
-
项目类别:
-
资助金额:$4.32万
-
财政年份:1985
-
负责人:CHARLES B LAWRENCE
-
依托单位:
MOLECULAR BIOLOGY INFORMATION RESOURCE
-
批准号:3565538
-
项目类别:
-
资助金额:$35.88万
-
财政年份:1985
-
负责人:CHARLES B LAWRENCE
-
依托单位:
MOLECULAR BIOLOGY INFORMATION RESOURCE
-
批准号:3450366
-
项目类别:
-
资助金额:$38.76万
-
财政年份:1985
-
负责人:CHARLES B LAWRENCE
-
依托单位:
MOLECULAR BIOLOGY INFORMATION RESOURCE
-
批准号:3450635
-
项目类别:
-
资助金额:$33.33万
-
财政年份:1985
-
负责人:CHARLES B LAWRENCE
-
依托单位:
MOLECULAR BIOLOGY INFORMATION RESOURCE
-
批准号:3450636
-
项目类别:
-
资助金额:$32.24万
-
财政年份:1985
-
负责人:CHARLES B LAWRENCE
-
依托单位:
MOLECULAR BIOLOGY INFORMATION RESOURCE
-
批准号:3450637
-
项目类别:
-
资助金额:$0.14万
-
财政年份:1985
-
负责人:CHARLES B LAWRENCE
-
依托单位:
MOLECULAR BIOLOGY INFORMATION RESOURCE
-
批准号:3450639
-
项目类别:
-
资助金额:$18.48万
-
财政年份:1985
-
负责人:CHARLES B LAWRENCE
-
依托单位:
MOLECULAR BIOLOGY INFORMATION RESOURCE
-
批准号:3450368
-
项目类别:
-
资助金额:$35.88万
-
财政年份:1985
-
负责人:CHARLES B LAWRENCE
-
依托单位:
REGULATION OF EUKARYOTIC GENE EXPRESSION
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批准号:3280005
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项目类别:
-
资助金额:$9.86万
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财政年份:1984
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负责人:CHARLES B LAWRENCE
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依托单位:
NUCLEAR SUBSTRUCTURE IN RNA PROCESSING AND TRANSPORT
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批准号:3128908
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项目类别:
-
资助金额:$12.35万
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财政年份:1983
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负责人:CHARLES B LAWRENCE
-
依托单位:
CORE--COMPUTATION
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批准号:3735804
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
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负责人:CHARLES B LAWRENCE
-
依托单位:
CORE--COMPUTATION
-
批准号:3757508
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
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负责人:CHARLES B LAWRENCE
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依托单位:
CORE--COMPUTATION
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批准号:3779403
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:CHARLES B LAWRENCE
-
依托单位:
CORE--COMPUTATION
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批准号:3843169
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
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负责人:CHARLES B LAWRENCE
-
依托单位:
CORE--COMPUTATION
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批准号:3857905
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:CHARLES B LAWRENCE
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依托单位:
海外基金