SYNTHESIS & SYNTHETIC UTILITY OF 1-ACYLDIHYDROPYRIDINES

本提案的目的是制定合成方法， 的新的1-酰基二氢吡啶，并研究其作为合成 中间体的 具体目标是：（1）研究不对称合成 1-酰基-2-烷基-1，2-二氢吡啶和2-烷基-2，3-二氢-4- 吡啶酮。(2)研究了不对称合成和合成 1-酰基-2-三苯基甲硅烷基-2，3-二氢-4-吡啶酮的用途。(3)到 开发各种吲哚里西啶的对映选择性合成， 使用纯手性2，3-二氢-4-吡啶酮作为 合成中间体 所提出的方法学将有助于化合物的合成 具有广泛的生物学特性，即神经安定剂， 抗高血压、抗炎、抗肿瘤和抗惊厥 活动

The objective of this proposal is to develop methods for the synthesis of novel 1-acyldihydropyridines and to study their utility as synthetic intermediates. Specific aims are (1) To study the asymmetric synthesis of 1-acyl-2-alkyl-1,2-dihydropyridines and 2-alkyl-2, 3-dihydro- 4 - pyridones. (2) To investigate the asymmetric synthesis and synthetic utility of 1-acyl-2-triphenylsilyl-2,3-dihydro-4-pyridones. (3) To develop enantioselective syntheses of various indolizidine and quinolizidine alkaloids using homochiral 2,3-dihydro-4-pyridones as synthetic intermediates. The proposed methodology will be useful for tbe synthesis of compounds having a broad range of biological properties, i.e. neuroleptic, antihypertensive, antiinflamatory, antitumor, and anticonvulsant activities.