SYNTHESIS & SYNTHETIC UTILITY OF 1-ACYLDIHYDROPYRIDINES

这项拟议工作的目标是开发合成方法 的新的1-酰基二氢吡啶，并研究其作为合成 中间体的 具体目标包括： 1. 研究了1-酰基-2-烷基= 1，2- 二氢吡啶和2-烷基-2，3-二氢-4-吡啶酮。 2. 研究了对映选择性全合成 链唑啉、大麻素和别普米利欧毒素。 3. 研究了一种对映选择性合成 通过手性二氢吡啶中间体合成各种石松生物碱。 所提出的方法将有助于化合物的合成 具有广泛的生物学特性，即神经安定剂， 抗高血压、抗炎、抗癌、抗艾滋病， 抗惊厥活性。

The objective of this proposed work is to develop methods for the synthesis of novel 1-acyldihydropyridines and to study their utility as synthetic intermediates. Specific aims include: 1. To study the asymmetric synthesis of 1-acyl-2-alkyl=1,2- dihydropyridines and 2-alkyl-2,3-dihydro-4-pyridones. 2. To study approaches to the enantioselective total synthesis of streptazolin, cannabisativine and allopumiliotoxin. 3. To investigate a general approach to enantioselective synthesis of various Lycopodium alkaloids via chiral dihydropyridine intermediates. The proposed methodology will be useful for the synthesis of compounds having a broad range of biological properties, i.e. neuroleptic, antihypertensive, anti-inflammatory, anticancer, anti-AIDS, and anticonvulsant activities.