SYNTHESIS & SYNTHETIC UTILITY OF 1-ACYLDIHYDROPYRIDINES

合成

• 批准号: 2391967
• 负责人: DANIEL L COMINS
• 金额: $ 25.51万
• 依托单位: NORTH CAROLINA STATE UNIVERSITY RALEIGH
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-01-01 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2391967
• 关键词: acylation; alkylation; cannabinoids; chemical synthesis; dihydropyridines; halocarbon compound; halogenation; heterocyclic compounds; organometallic compounds; stereochemistry

The objective of this proposed work is to develop methods for the synthesis of novel 1-acyldihydropyridines and to study their utility as synthetic intermediates. Specific aims include: 1. To study the asymmetric synthesis of 1-acyl-2-alkyl=1,2- dihydropyridines and 2-alkyl-2,3-dihydro-4-pyridones. 2. To study approaches to the enantioselective total synthesis of streptazolin, cannabisativine and allopumiliotoxin. 3. To investigate a general approach to enantioselective synthesis of various Lycopodium alkaloids via chiral dihydropyridine intermediates. The proposed methodology will be useful for the synthesis of compounds having a broad range of biological properties, i.e. neuroleptic, antihypertensive, anti-inflammatory, anticancer, anti-AIDS, and anticonvulsant activities.

这项拟议工作的目的是发展合成的方法