SYNTHESIS AND SYNTHETIC UTILITY OF 1-ACYLDIHYDROPYRIDINE

描述：(主要调查人员摘要)这项建议的目标 工作是开发合成新的1-酰基二氢吡啶的方法 和二氢吡啶酮，并研究它们作为合成中间体的用途。 具体目标包括： 1.继续研究不对称合成和反应 1-酰基-2-烷基-1，2-二氢吡啶和2，3-二氢-4-吡啶酮。 2.完成链他唑林的对映选择性全合成， 大麻素和别普利奥毒素。 3.探索不对称合成各种不对称化合物的一般方法 石松生物碱通过手性二氢吡啶中间体。 所提出的方法学将对合成具有 广泛的生物学特性，如抗精神病药、抗高血压、 具有抗炎、抗癌、抗艾滋病、抗惊厥等活性。

DESCRIPTION: (Principal Investigator's Abstract) The objective of this proposed work is to develop methods for the synthesis of novel 1-acyldihydropyridines and dihydropyridones and to study their utility as synthetic intermediates. Specific aims include: 1. To continue studying the asymmetric synthesis and reactions of 1-acyl-2-alkyl 1,2-dihydropyridines and 2,3-dihydro-4-pyridones. 2 .To complete the enantioselective total syntheses of streptazolin, cannabisativine and allopumiliotoxin. 3 .To investigate a general approach to enantioselective synthesis of various lycopodium alkaloids via chiral dihydropyridine intermediates. The proposed methodology will be useful for the synthesis of compounds having a broad range of biological properties, i.e. neuroleptic, antihypertensive, anti-inflammatory, anticancer, anti-AIDS, and anticonvulsant activities.