ANTITUMOR/ANTIBIOTIC SUBSTANCES: SYNTHESIS AND CHEMISTR

这项研究有几个目标。一是发展化学药品 某些具有抗肿瘤、抗病毒或抗病毒活性的复杂分子的合成 一种特殊的抗生物活性。为了让这样的合成 实用性和足够的灵活性，以允许生产广泛的 必须开发结构类似物、新的合成反应和方法学。 因此，第二个目标是发现新的合成原理和方法， 为了扩大我们的能力来实现最具挑战性的 打字。在最一般的意义上，我们寻求扩大有机合成的力量 医学的进步很大程度上最终依赖于它，同时 时间来实现重要物质的合成。 拟开展的研究主要围绕以下生物活性展开 物质或物质族：1)美坦辛，2)红霉素，3) 奥兰霉素，4)阿普莫霉素，5)利福霉素，6)科里奥林，7)二酮，8) 卵黄素、干扰素诱导物质和环状cMP类似物。 最后，我们的目标是，通过这些化学研究，使 对医学的贡献。

There are several objectives of this research. One is to develop chemical syntheses of certain complex molecules showing antitumor, antiviral or antiobiotic activity of an exceptional sort. In order for such syntheses to be practical and sufficiently flexible to allow the production of a wide range of structural analogs, new synthetic reactions and methodology must be developed. A second goal, therefore, is to discover new synthetic principles and methods, in order to extend our capacity to effect syntheses of the most challenging type. In a most general sense we seek to extend the power of organic synthesis upon which much of the progress of medicine ultimately depends and at the same time to achieve the synthesis of important substances. The proposed research centers around the following biologically active substances or families of substances: 1) maytansines, 2) erythromycins, 3) oleandomycin, 4) aplasmomycin, 5) rifamycins, 6) coriolins, 7) quadrone, 8) ovalicin, 9) interferon inducing substances and 10) cyclic CMP analogs. Finally, it is our aim, through these chemical studies, to make significant contributions to medicine.