ANTITUMOR/ANTIBIOTIC SUBSTANCES: SYNTHESIS AND CHEMISTR

抗肿瘤/抗生素物质：合成和化学

• 批准号: 3284707
• 负责人: ELIAS J COREY
• 金额: $ 50.88万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-12-01 至 1989-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3284707
• 关键词: antineoplastic antibiotics; antiviral agents; chemical structure function; cyclic AMP; drug design /synthesis /production; drug metabolism; erythromycin; interferons; neoplasm /cancer chemotherapy; rifamycins; stereochemistry

There are several objectives of this research. One is to develop chemical syntheses of certain complex molecules showing antitumor, antiviral or antiobiotic activity of an exceptional sort. In order for such syntheses to be practical and sufficiently flexible to allow the production of a wide range of structural analogs, new synthetic reactions and methodology must be developed. A second goal, therefore, is to discover new synthetic principles and methods, in order to extend our capacity to effect syntheses of the most challenging type. In a most general sense we seek to extend the power of organic synthesis upon which much of the progress of medicine ultimately depends and at the same time to achieve the synthesis of important substances. The proposed research centers around the following biologically active substances or families of substances: 1) maytansines, 2) erythromycins, 3) oleandomycin, 4) aplasmomycin, 5) rifamycins, 6) coriolins, 7) quadrone, 8) ovalicin, 9) interferon inducing substances and 10) cyclic CMP analogs. Finally, it is our aim, through these chemical studies, to make significant contributions to medicine.

这项研究有几个目标。 一是发展化学 合成某些显示抗肿瘤、抗病毒或 具有特殊的抗菌活性。 为了使这种合成能够 实用且足够灵活，可以生产各种 必须开发结构类似物、新的合成反应和方法。 因此，第二个目标是发现新的合成原理和方法， 为了扩大我们的能力，以实现最具挑战性的合成， 类型. 在最一般的意义上，我们寻求扩大有机合成的能力， 医学的进步最终取决于此，同时， 时间来实现重要物质的合成。 拟议的研究中心围绕以下生物活性 物质或物质家族：1）美登素类，2）红霉素类，3） 竹桃霉素，4）无规霉素，5）利福霉素，6）柯黎素，7）四氢呋喃酮，8） 9）干扰素诱导物质和10）环状CMP类似物。 最后，我们的目标是，通过这些化学研究， 对医学的贡献。