ANTITUMOR/ANTIBIOTIC SUBSTANCES--SYNTHESIS AND CHEMISTRY

抗肿瘤/抗生素物质——合成和化学

• 批准号: 3284710
• 负责人: ELIAS J COREY
• 金额: $ 53.58万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-12-01 至 1990-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3284710
• 关键词: antineoplastic antibiotics; antineoplastics; antiviral agents; chemical structure function; cyclic AMP; drug design /synthesis /production; drug metabolism; erythromycin; interferons; neoplasm /cancer chemotherapy; rifamycins; stereochemistry

There are several objectives of this research. One is to develop chemical syntheses of certain complex molecules showing antitumor, antiviral or antiobiotic activity of an exceptional sort. In order for such syntheses to be practical and sufficiently flexible to allow the production of a wide range of structural analogs, new synthetic reactions and methodology must be developed. A second goal, therefore, is to discover new synthetic principles and methods, in order to extend our capacity to effect syntheses of the most challenging type. In a most general sense we seek to extend the power of organic synthesis upon which much of the progress of medicine ultimately depends and at the same time to achieve the synthesis of important substances. The proposed research centers around the following biologically active substances or families of substances: 1) maytansines, 2) erythromycins, 3) oleandomycin, 4) aplasmomycin, 5) rifamycins, 6) coriolins, 7) quadrone, 8) ovalicin, 9) interferon inducing substances and 10) cyclic CMP analogs. Finally, it is our aim, through these chemical studies, to make significant contributions to medicine.

这项研究有几个目的。一个是发展化学