Sustainable Control of Parasites in Ewes (SCOPE)

母羊寄生虫的可持续控制 (SCOPE)

• 批准号: BB/X000923/1
• 负责人: Hannah Vineer
• 金额: $ 66.33万
• 依托单位: University of Liverpool
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FX000923%2F1
• 关键词: Sustainable; Control; Parasites; Ewes; SCOPE

This project will slow the development of anthelmintic resistance (AR) in UK sheep flocks by developing and promoting evidence-based strategies for sustainable treatment of ewes at lambing time. Guidelines for the sustainable control of parasites in ewes (SCOPE) will be developed by quantifying the production and epidemiological impacts of periparturient ewe treatments and simulating selection for anthelmintic resistance under a range of flock management strategies and climatic conditions, using gastrointestinal nematode (GIN) epidemiological models that I have already developed. The project addresses a STAR-IDAZ International Research Consortium in Animal Health's priority research topic and several key challenges. By providing farmers with information and guidance to help them minimise inputs whilst at the same time upholding high standards of welfare and productivity, the project also aligns with Defra's Animal Health and Welfare Pathway.Helminth infections are a major economic and welfare burden to UK ruminant production enterprises, costing the UK sheep industry an estimated £41m per year. Parasitic gastroenteritis and anthelmintic resistance (AR) are now considered by UK industry professionals to be the second most important sheep disease and syndrome in the UK. GIN infections in periparturient ewes are of particular concern due to the direct effects of infection on lamb exposure to infection. Most UK farmers treat periparturient ewes with moxidectin, yet treating ewes at lambing time has the potential to select heavily for AR. Despite this risk, the epidemiological and evolutionary impacts of anthelmintic treatment of periparturient ewes on GIN populations have not yet been robustly quantified. To date, no controlled, randomised study investigating the impact of ewe treatments on AR has been conducted in the UK, nor in Europe, and no studies of this nature have investigated the use of moxidectin.The overarching aim of this project is to provide an evidence base for industry guidelines for the sustainable use of anthelmintics to control GIN in ewes, which promote high levels of welfare and productivity, yet slow the development of AR.We will achieve this with three specific objectives which combine empirical parasitology, population genetic analyses and mathematical modelling.1. Quantify the consequences of ewe treatments for GIN epidemiology, AR, GIN population diversity, and lamb productivity2. Develop and validate a mathematical model to simulate the development of AR following anthelmintic treatment of ewes3. Simulate the outcome of treatment strategies for controlling the PPR-FEC in ewes throughout the UK, and determine the most sustainable regional approachesWe will work closely with industry stakeholders throughout, including project partners, to develop guidelines/recommendations for the sustainable anthelmintic control of parasites in ewes. These will be disseminated through partners and at industry events, and the impact of our research will be evaluated through farmer surveys of behaviour change. The outcomes of this research will feed directly in to updated nationwide industry guidelines for the sustainable control of parasites in ewes.

该项目将通过开发和推广基于证据的策略，在产羔期对母羊进行可持续治疗，减缓英国羊群抗蠕虫药（AR）的发展。将通过量化围产期母羊治疗的生产和流行病学影响，并在一系列羊群管理策略和气候条件下模拟选择驱虫剂抗性，使用我已经开发的胃肠道线虫（GIN）流行病学模型，制定可持续控制母羊寄生虫的指南（SCOPE）。该项目涉及STAR-IDAZ动物健康国际研究联盟的优先研究课题和几个关键挑战。通过为农民提供信息和指导，帮助他们最大限度地减少投入，同时保持高标准的福利和生产力，该项目也符合Defra的动物健康和福利途径。蠕虫感染是英国反刍动物生产企业的主要经济和福利负担，每年给英国养羊业造成的损失估计为4100万英镑。寄生虫性胃肠炎和驱虫药耐药性（AR）现在被英国行业专业人士认为是英国第二大绵羊疾病和综合征。由于感染对羔羊暴露于感染的直接影响，围产期母羊的GIN感染特别令人关注。大多数英国农民用莫昔克丁治疗围产期母羊，但在产羔时治疗母羊有可能严重选择AR。尽管存在这种风险，但尚未对围产期母羊驱虫治疗对GIN人群的流行病学和进化影响进行有力的量化。迄今为止，在英国和欧洲均未开展调查母羊治疗对AR影响的对照、随机研究，也未开展此类性质的研究调查莫昔克丁的使用。本项目的总体目标是为可持续使用驱虫药控制母羊GIN的行业指南提供证据基础，从而促进高水平的福利和生产力，我们将通过结合联合收割机经验寄生虫学、种群遗传分析和数学建模的三个具体目标来实现这一目标。量化母羊治疗对GIN流行病学、AR、GIN种群多样性和羔羊生产力的影响2。开发并验证数学模型，以模拟绵羊驱虫治疗后AR的发展3。模拟控制全英国母羊PPR-FEC的治疗策略的结果，并确定最可持续的区域方法我们将与包括项目合作伙伴在内的行业利益相关者密切合作，制定可持续驱虫控制母羊寄生虫的指南/建议。这些将通过合作伙伴和行业活动传播，我们的研究的影响将通过农民行为变化调查进行评估。这项研究的结果将直接用于更新全国范围内可持续控制母羊寄生虫的行业指南。