Exploring unique osmoregulatory adaptations in a globally devastating insect pest
探索全球毁灭性害虫的独特渗透调节适应
基本信息
- 批准号:BB/X014703/1
- 负责人:
- 金额:$ 72.86万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2023
- 资助国家:英国
- 起止时间:2023 至 无数据
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Beetles are small in size and have large surface area (relative to their volume) which makes them prone to desiccation, and yet many species can live and thrive in very dry habitats, such as deserts. It is therefore unsurprising that they possess efficient ways to regulate their water budget. Some species are so efficient in conserving water they are able to live without access to drinking water. This is true for a species known as the red flour beetle, which lives its entire lifecycle in dry flour. Such is its success at living in these conditions the red flour beetle has risen to become a globally distributed and devastating agricultural pest. While it is clear beetles are extraordinarily well equipped to survive in dry habitats, the underlying reasons that allow them to do so are not. The main organs that control water balance in insects is known, but it appears that these organs in beetles are arranged and function in a radically different way compared to all other insects. The overarching aim of this proposal is to understand how these organs form and function. Our project focuses on the organs that control water budget. We will determine how they function by creating an atlas of the cells they contain. This atlas, based on the types of genes that are differentially expressed between cells, will allow us to predict cell functions and provide clues to which genes are important for these functions. We will carry out similar experiments during development to illuminate the mechanisms underpinning the generation of these organs. We are able to manipulate the activity of specific genes, which allows us to understand the role of a particular gene and its product in controlling how the organs form and function, and ultimately how this effects the beetle's water budget. We will extend our analyses by comparing the flour beetle to the fruit fly to help pinpoint similarities and differences between species that will provide clues to how these differences arose during organ evolution. The work will generate knowledge that will transform our understanding of the largest animal group on the planet, and specifically about a widespread and devastating pest species. The work has the potential to lead to novel pest control approaches.
甲虫体积小,表面积大(相对于它们的体积),这使得它们容易干燥,但许多物种可以在非常干燥的栖息地(如沙漠)中生存和繁荣。因此,毫不奇怪,他们拥有有效的方法来调节其水预算。有些物种在保存水方面非常有效,它们能够在没有饮用水的情况下生存。对于一种被称为红粉甲虫的物种来说,这是真的,它的整个生命周期都生活在干面粉中。这就是它在这些条件下的成功,红粉甲虫已经成为一种全球分布和毁灭性的农业害虫。虽然很明显,甲虫在干燥的栖息地生存的条件非常好,但允许它们这样做的根本原因却不是这样。控制昆虫体内水分平衡的主要器官是已知的,但与所有其他昆虫相比,甲虫的这些器官似乎以完全不同的方式排列和发挥作用。本提案的总体目标是了解这些器官的形成和功能。我们的项目重点关注控制水预算的器官。我们将通过创建它们所包含的细胞图谱来确定它们如何发挥作用。这个图谱基于细胞间差异表达的基因类型,将使我们能够预测细胞功能,并提供哪些基因对这些功能重要的线索。我们将在发育过程中进行类似的实验,以阐明这些器官产生的机制。我们能够操纵特定基因的活动,这使我们能够了解特定基因及其产物在控制器官形成和功能方面的作用,以及最终如何影响甲虫的水预算。我们将通过比较面粉甲虫和果蝇来扩展我们的分析,以帮助确定物种之间的相似性和差异,这将为器官进化过程中这些差异是如何产生的提供线索。这项工作将产生的知识,将改变我们对地球上最大的动物群体的理解,特别是关于一种广泛而毁灭性的害虫物种。这项工作有可能导致新的害虫控制方法。
项目成果
期刊论文数量(0)
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Barry Denholm其他文献
03-P067 The control of convergent-extension movements in a tubular epithelium
- DOI:
10.1016/j.mod.2009.06.120 - 发表时间:
2009-08-01 - 期刊:
- 影响因子:
- 作者:
Barry Denholm;Stephanie Bunt;Claire Hooley;Helen Skaer - 通讯作者:
Helen Skaer
Evidence for the independent evolution of a rectal complex within the beetle superfamily Scarabaeoidea
甲虫总科金龟子科直肠复合体独立进化的证据
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Robin Beaven;Barry Denholm;Maria Fremlin;Davide Scaccini - 通讯作者:
Davide Scaccini
03-P063 Molecular function of crossveinless-c in Drosophila Malpighian tubule morphogenesis
- DOI:
10.1016/j.mod.2009.06.116 - 发表时间:
2009-08-01 - 期刊:
- 影响因子:
- 作者:
Aditya Saxena;Barry Denholm;Helen Skaer - 通讯作者:
Helen Skaer
Barry Denholm的其他文献
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{{ truncateString('Barry Denholm', 18)}}的其他基金
Emergence of functional polarity in a tubular epithelium: a mechanistic study
管状上皮功能极性的出现:机制研究
- 批准号:
BB/N001281/1 - 财政年份:2016
- 资助金额:
$ 72.86万 - 项目类别:
Research Grant
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