GENOME EVOLUTION--POPULATION GENETIC ASPECTS

基因组进化——群体遗传方面

• 批准号: 3293748
• 负责人: J. Bruce WALSH
• 金额: $ 2.96万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 1991-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3293748
• 关键词: biochemical evolution; gene conversion; gene duplication; genetic models; genetic recombination; genome; molecular genetics; natural gene amplification; natural selections; nucleic acid sequence; population genetics

The goal of this work is to extend our understanding of how evolution acts on the molecular structure of genomes. Three general areas will be investigated using theoretical population genetic models: pseudogene distributions, copy number dynamics in tandem arrays, and divergence of duplicated genes under homology-dependent conversion. Examination of pseudogene distribution provides an indicator of the relative effectiveness of selection in multigene families and may allow for discrimination, based on empirical data, of the nature of selection acting on a particular family. A more complete theory of copy number dynamics in tandem arrays is essential for understanding both satellite DNA turnover between related taxa and the behavior of runs of simple sequence DNAs (which often form restriction polymorphism markers used in genetic screening). Dynamics of divergence under homology-dependent gene conversion informs us how long individual genes remain part of a multigene family and is of considerable importance in developing theoretical models of evolution of new gene function via gene duplication. Theoretical models often suggest areas for future empirical work which are not obvious. An integral part of the proposed research is testing model predictions and assumptions from empirical data, and to strive to make testable predictions in little-examined areas of genome evolution. Thus, the proposed work examines functional, as well as evolutionary, aspects of genome organization from a rather different prospective than is normally used.

这项工作的目标是扩大我们的理解， 进化作用于基因组的分子结构。 三 将使用理论种群对一般区域进行研究 遗传模型：假基因分布，拷贝数动态 在串联阵列中，重复基因在 同源依赖性转换。 假基因检查 分布提供了一个指标的相对有效性 在多基因家族中进行选择，并且可能允许区分， 根据经验数据，选择的性质作用于一个 特别的家庭。 更完整的拷贝数理论 串联阵列中的动力学对于理解 相关类群之间的卫星DNA周转和 简单序列DNA的运行（通常形成限制 遗传筛选中使用的多态性标记）。 动力学 同源依赖基因转换的分歧告诉我们， 单个基因在多基因家族中存在多久， 在发展理论模型方面具有相当重要的意义， 通过基因复制进化新的基因功能。 理论模型通常为未来的实证工作提供建议 这并不明显。 拟议研究的一个组成部分 是从经验数据中测试模型预测和假设， 并努力在很少被检验的领域做出可检验的预测 基因组进化。 因此，拟议的工作审查 基因组的功能和进化方面 从一个与通常不同的角度来看， 采用