Neural mechanisms of vestibular perception in zebrafish

斑马鱼前庭感知的神经机制

• 批准号: DP170102827
• 负责人: Prof Ethan Scott
• 金额: $ 27.95万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170102827
• 关键词: Neural; mechanisms; vestibular; perception; zebrafish

This project aims to understand vestibular processing by removing physical movement. The vestibular system allows us to perceive gravity and movement, but it is not understood how the brain processes information from vestibular sensors in the inner ear. This project will exert forces on the zebrafish’s inner ear with a laser, stimulating the vestibular sense. This means that the animal will experience vestibular stimuli while stationary, allowing calcium imaging of neurons that respond to vestibular cues and optogenetics to stimulate or silence these neurons. This is expected to reveal which cells and circuits mediate vestibular perception, processing and behaviour.

该项目旨在通过消除身体运动来了解前庭处理。前庭系统使我们能够感知重力和运动，但目前还不清楚大脑如何处理来自内耳前庭传感器的信息。该项目将用激光对斑马鱼的内耳施加力，刺激前庭感觉。这意味着动物将在静止时经历前庭刺激，从而允许响应前庭线索的神经元的钙成像和光遗传学刺激或沉默这些神经元。这有望揭示哪些细胞和回路介导前庭感知，处理和行为。