Mapping a complete visual circuit in zebrafish

绘制斑马鱼完整的视觉回路

• 批准号: DP200102885
• 负责人: Prof Ethan Scott
• 金额: $ 32.64万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200102885
• 关键词: Mapping; complete; visual; circuit; zebrafish

Our senses perceive the outside world and permit appropriate behaviours, but the underlying brain circuits are poorly understood. This project will use new technologies to observe all active brain cells in zebrafish during the important behaviour of visual predator avoidance and characterise the underlying circuits comprehensively. This approach's significance is in its breadth, spanning functional imaging, anatomy, computational modelling, and behaviour, with the major outcome of producing the first complete map of a visual behaviour at the level of brain circuits and the individual brain cells composing them. Benefits will include new insights into visual processing and the refinement of new genetic, optical, and informatics approaches.

我们的感官感知外部世界，并允许适当的行为，但底层的大脑回路知之甚少。该项目将使用新技术观察斑马鱼在视觉捕食者回避的重要行为期间所有活跃的脑细胞，并全面研究潜在的回路。这种方法的意义在于其广度，跨越功能成像，解剖学，计算建模和行为，主要成果是在脑回路和组成它们的单个脑细胞水平上产生第一个完整的视觉行为图。好处将包括对视觉处理的新见解和新的遗传，光学和信息学方法的改进。