Cerebellar control of classical conditioning

小脑对经典条件反射的控制

• 批准号: DP140102036
• 负责人: Prof Ethan Scott
• 金额: $ 25.9万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140102036
• 关键词: Cerebellar; control; classical; conditioning

This project proposes to use zebrafish, in combination with optogenetics, to identify and test patterns of neural activity that are responsible for classical conditioning. It will do this by describing the connections between the cerebellum and other brain regions, and by observing patterns of neural activity as learning takes place. Next, the project will block or recreate these patterns of activity to see whether they are necessary or sufficient for learning. The goal is to describe, in concrete terms, how patterns of neural activity in this part of the brain result in learning. In so doing, the project also aims to develop and test new technologies and approaches for studying the functioning brain.

该项目建议使用斑马鱼与光遗传学相结合，以识别和测试负责经典条件反射的神经活动模式。它将通过描述小脑和其他大脑区域之间的联系，以及通过观察学习发生时的神经活动模式来做到这一点。接下来，该项目将阻止或重新创建这些活动模式，看看它们是否对学习是必要的或足够的。我们的目标是用具体的术语来描述大脑这一部分的神经活动模式是如何导致学习的。在这样做的过程中，该项目还旨在开发和测试研究大脑功能的新技术和方法。