Neural mechanisms of water flow perception and spatial integration

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This project aims to develop a novel zebrafish platform for elucidating the circuits that mediate lateral line perception. The sensory modality by which fish detect and respond to water flow is poorly understood. This project proposes a novel preparation in the zebrafish model for applying controlled water flow using microfluidics, thereby stimulating the lateral line. Because the animal remains stationary, it is possible to perform whole-brain calcium imaging of cells and circuits that respond to water flow, and to use optogenetics to stimulate or silence these neurons. This will reveal the circuitry mediating flow perception, and its relationship with other senses, in a way that has been previously impossible.