Brain states and their roles in evasive behaviour

大脑状态及其在逃避行为中的作用

• 批准号: DP230102614
• 负责人: Prof Ethan Scott
• 金额: $ 59.81万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230102614
• 关键词: Brain; states; their; roles; evasive

Using cutting-edge custom microscopy, neuroinformatics, and optogenetics in the larval zebrafish model, this project aims to describe the neurons, circuits, and networks that govern brain states. These brain states, by altering sensory-response relationships, allow animals to tune their behaviour to their circumstances, and the small transparent brains of zebrafish offer the possibility to observe activity across all neurons in the brain while these processes occur in real time. Benefits would include knowledge gained about this fundamental property of the brain, further refinement of technologies in microscopy and biophyisics, and the training of Australia’s next generation of optical physicists, neuroscientists, and mathematicians.

在斑马鱼幼虫模型中使用尖端的定制显微镜，神经信息学和光遗传学，该项目旨在描述控制大脑状态的神经元，电路和网络。通过改变感觉-反应关系，这些大脑状态允许动物根据环境调整自己的行为，而斑马鱼的小透明大脑提供了观察大脑中所有神经元活动的可能性，同时这些过程正在实时发生。其好处包括获得关于大脑这一基本属性的知识，进一步完善显微镜和生物物理学技术，以及培养澳大利亚下一代光学物理学家、神经科学家和数学家。