Development of a Chemoproteomics Centre of Excellence: A Prosperity Partnership for Drug Discovery in Northern Ireland

化学蛋白质组学卓越中心的发展：北爱尔兰药物发现的繁荣伙伴关系

• 批准号: BB/Y00325X/1
• 负责人: Christopher Scott
• 金额: $ 335.05万
• 依托单位: Queen's University Belfast
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FY00325X%2F1
• 关键词: Development; Chemoproteomics; Centre; Excellence; Prosperity

In this BBSRC Prosperity Partnership, Queen's University Belfast (QUB) and Almac Discovery will bring together their joint expertise to create a new state-of-the-art Chemoproteomics Centre of Excellence situated within QUB; this will be the first of its kind in the Northern Ireland region. Specifically, we will use the Prosperity Partnership to co-develop a new mass spectrometry proteomics facility that can study molecular changes in proteins from cells and tissues treated with therapeutic drugs and drug-like molecules ("chemical probes"). This facility builds on a well-established relationship between the partners in basic biological research and early-stage drug discovery (Almac), leveraging the capabilities and state-of-the-art expertise of QUB researchers in mass spectrometry and basic and translational biological research (namely inflammation, cell death and ion channels) across three University Research Centres (Cancer, Experimental Medicine and Pharmacy). The Centre of Excellence will provide completely new chemical tools that will open new areas of biology and a mass spectrometry platform that will benefit both partners, thereby enabling cutting-edge biological research and drug discovery. It is also envisaged that this facility will provide opportunities for other collaborators, both academic and industrial, to advance their basic research and R&D portfolios, providing a business model that will ensure that this Centre of Excellence will continue to support academic and industrial R&D in the region beyond the life of this project. Not only will the Centre of Excellence enhance our regional capabilities, it will also provide skills training for apprenticeships through to doctoral researchers and create value in the forms of new drugs, intellectual property and high quality academic publications (reputation). Thus, the Centre of Excellence will encourage inward investment and sectorial growth in Northern Ireland, helping to "level up" the capacity and contribution of the Northern Ireland Life Sciences sector to the broader UK economy. This is in line with both regional (10X economy, Department for Economy) and Life Sciences Vision (UK) strategies. Our ultimate vision is to build an internationally recognised regional resource whose chemical probes, experimental capabilities, knowledge and expertise can assist the research and development programmes of other regional, national and international industrial and academic partners. Thus, the creation of this industry-facing, University-based facility represents a unique opportunity to provide a step-change in proteomics-based experimental capabilities in Northern Ireland.

在这个BBSRC繁荣合作伙伴关系中，贝尔法斯特女王大学（QUB）和Almac Discovery将汇集他们的共同专业知识，在贝尔法斯特女王大学（QUB）内创建一个新的最先进的化学蛋白质组学卓越中心；这将是北爱尔兰地区首个此类项目。具体而言，我们将利用繁荣伙伴关系共同开发一种新的质谱蛋白质组学设备，该设备可以研究经过治疗药物和药物样分子（“化学探针”）处理的细胞和组织中蛋白质的分子变化。该设施建立在基础生物学研究和早期药物发现（Almac）合作伙伴之间建立的良好关系之上，利用昆士兰大学三个大学研究中心（癌症、实验医学和药学）的研究人员在质谱和基础和转化生物学研究（即炎症、细胞死亡和离子通道）方面的能力和最先进的专业知识。卓越中心将提供全新的化学工具，开辟新的生物学领域，并提供一个质谱平台，使双方都受益，从而实现尖端的生物学研究和药物发现。此外，该设施还将为其他学术和工业合作伙伴提供机会，以推进他们的基础研究和研发组合，提供一种商业模式，确保该卓越中心在项目结束后继续支持该地区的学术和工业研发。卓越中心不仅将提升我们的区域能力，还将提供从学徒到博士研究人员的技能培训，并以新药、知识产权和高质量学术出版物（声誉）的形式创造价值。因此，卓越中心将鼓励北爱尔兰的外来投资和行业增长，帮助“提升”北爱尔兰生命科学部门的能力和对更广泛的英国经济的贡献。这符合区域（10X经济，经济部）和生命科学愿景（英国）战略。我们的最终愿景是建立一个国际认可的区域资源，其化学探针，实验能力，知识和专业知识可以协助其他区域，国家和国际工业和学术合作伙伴的研究和发展计划。因此，这个面向行业、以大学为基础的设施的创建代表了一个独特的机会，可以在北爱尔兰提供基于蛋白质组学的实验能力的逐步改变。