Mechanisms of negative feedback regulation of GnRH by testosterone in males

男性睾酮对 GnRH 的负反馈调节机制

• 批准号: nhmrc : 124352
• 负责人: Christopher Scott
• 金额: $ 16.23万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-negative-feedback-testosterone-males/77564
• 关键词: Mechanisms; negative; feedback; regulation; GnRH

This project will improve our knowledge of the hormonal control of reproduction in males. The hormone testosterone, produced by the testes, acts on the brain to control the secretion of a substance called gonadotrophin releasing hormone (GnRH). GnRH acts on a small gland at the base of the brain to cause the production of hormones called gonadotrophins, that are essential for reproduction. These gonadotrophins act on the testes to ensure the production of sperm and other hormones, including testosterone. We plan to determine how testosterone acts on the brain to control GnRH secretion. To do this we will use male sheep and conduct a series of experiments designed to show where in the brain testosterone acts to ultimately affect the nerve cells that produce GnRH. Testosterone and similar compounds are increasingly being used as treatments for infertility, as a male contraception and misused as anabolic steroids. A thorough knowledge of how testosterone acts in the brain is necessary to improve treatments for reproductive disorders and ultimately to improve reproductive health in men.

这个项目将提高我们对雄性生殖的荷尔蒙控制的知识。由睾丸产生的激素睾丸素作用于大脑，控制一种名为促性腺激素释放激素(GnRH)的物质的分泌。促性腺激素释放激素作用于大脑底部的一个小腺体，产生称为促性腺激素的激素，这是生殖所必需的。这些促性腺激素作用于睾丸，以确保精子和其他激素的产生，包括睾丸素。我们计划确定睾丸激素如何作用于大脑来控制GnRH的分泌。为了做到这一点，我们将使用雄性绵羊并进行一系列实验，旨在展示睾丸激素在大脑中的作用最终影响产生促性腺激素释放激素的神经细胞。睾酮和类似化合物越来越多地被用作不育症的治疗，作为男性避孕药，并被误用为合成类固醇。彻底了解睾丸激素在大脑中的作用，对于改善生殖障碍的治疗，并最终改善男性的生殖健康是必要的。