METALLOENZYME SITES--SYNTHESES AND BIOMIMETIC CHEMISTRY

金属酶位点——合成和仿生化学

• 批准号: 3297273
• 负责人: TEDDY G. TRAYLOR
• 金额: $ 15.13万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 1991-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3297273
• 关键词: Diels Alder reaction; azurin; chemical synthesis; cyclic compound; hemerythrin; hemocyanin; heterocyclic compounds; imidazole; ligands; metalloenzyme; organic chemicals; thioether; thiols

The active site sections of the metalloproteins hemerythrin, hemocyanine, and azurine will be synthesized by attaching the appropriate numbers of imidazoles, thiol groups, and/or thioether groups to bicyclic organic compounds so that all the metal liganding groups are held, by the organic structure, in the same relative positions they occupy in natural systems. This will be accomplished by various metal-catalyzed coupling reactions, Diels-Alder reactions, and imidazole ring syntheses. New synthetic methodology will be developed for coupling and Diels- Alder reactions involving imidazoles and other heterocycles. The biomimetic behavior of the metal complexes of the synthetic site molecules will be studied by fast kinetic and various spectroscopic methods. The application of these synthetic procedures to the preparation of a variety of other multi-imidazoles containing active sites will also be explored.

金属蛋白血红素的活性部位， Hemorrhiza和天青将通过连接 适当数量的咪唑、硫醇基和/或硫醚 基团到双环有机化合物，使得所有的金属 配体基团通过有机结构保持在相同的 它们在自然系统中的相对位置。 这将是 通过各种金属催化的偶联反应完成， Diels-Alder反应和咪唑环合成。 新 合成方法学将被开发用于耦合和Diels- 涉及咪唑和其它杂环的桤木反应。 的 合成位点金属配合物的仿生行为 分子将被研究的快速动力学和各种光谱 方法. 将这些合成方法应用于 制备各种其它多咪唑， 此外，亦会研究活跃的地点。