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MECHANISM OF REACTIONS OF BLEOMYCIN-IRON AND RELATED IRO

MECHANISM OF REACTIONS OF BLEOMYCIN-IRON AND RELATED IRO
博莱霉素铁及相关 IRO 的反应机制
批准号：
3184034
负责人：
TEDDY G. TRAYLOR
金额：
$8.23万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
1986
资助国家：
美国
项目状态：
已结题
起止时间：
1986-04-01 至 1989-03-31
来源：
https://reporter.nih.gov/project-details/3184034
关键词：
DNA antineoplastics bleomycin carbon monoxide chemical kinetics chemical reaction cyanides heme iron nuclear magnetic resonance spectroscopy oxidation photochemistry respiratory oxygen ultraviolet spectrometry

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英文摘要
It is proposed to study the kinetics and mechanisms of reaction of bleomycin-iron(II) and several synthetic analogues with carbin monixide, isonitriles and dioxygen in order to clarify the mechanisms of its activation by dioxygen and the effect of DNA binding on this activation. The reaction of BLM-Fe(II) with oxygen atom donors and subsequent substrate oxidation will be compared with similar processes using hemin catalysts. Oxidation of a DNA "monomer unit" will be carried out using BLM-Fe and hemin catalysts in order to determine the mechanism of this reaction. New analogues of BLM will be prepared and tested as DNA cleaving reagents.
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