APPLICATION OF CARBON DIOXIDE IN THE SYNTHESIS OF HYDROPHILIC POLY(CARBONATE)S AS NOVEL BIODEGRADABLE HYDROGEL MATERIALS

二氧化碳在新型可生物降解水凝胶材料亲水性聚碳酸酯合成中的应用

• 批准号: EP/F068808/1
• 负责人: Andrew Dove
• 金额: $ 18.22万
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FF068808%2F1
• 关键词: APPLICATION; CARBON; DIOXIDE; SYNTHESIS; HYDROPHILIC

This proposal examines the synthesis and application of polymers derived from carbon dioxide as novel biodegradable hydrogel materials. Hydrogels are an important class of material that find numerous applications including tissue engineering and drug-delivery. The application of mechanically strong yet degradable materials such as poly(carbonate)s will provide improved materials in this arena. In addition to the importance of the final products resulting from this work, the proposal also deals with the development of new technology for the utilization of carbon dioxide as a chemical feedstock. The synthesis of hydrophilic poly(carbonate)s remains a significant challenge. Recent advances in catalyst technology have seen the realization of extremely active metal complexes for the alternating copolymerization of carbon dioxide with propylene oxide and this proposal will study the optimization of these systems for a range of new substituted hydrophilic and latent hydrophilic monomer feedstocks. In addition this proposal will, for the first time, examine the synthesis of multi-functional and responsive poly(carbonate)s by this methodology. The combination of these fundamental studies will result in the application of several novel copolymers in hydrogel synthesis allowing the production, characterization and evaluation of the properties of these highly novel materials as a function of polymer functionality and structure.

本提案研究了二氧化碳衍生聚合物作为新型生物可降解水凝胶材料的合成和应用。水凝胶是一类重要的材料，有着广泛的应用，包括组织工程和药物输送。应用机械强度高但可降解的材料，如聚碳酸酯S，将在这一领域提供改进的材料。除了这项工作产生的最终产品的重要性外，该提案还涉及开发利用二氧化碳作为化学原料的新技术。亲水性聚碳酸酯S的合成仍然是一个巨大的挑战。在催化剂技术的最新进展中，实现了用于二氧化碳和环氧丙烷交替共聚的极其活性的金属络合物，本提案将研究这些体系对一系列新的取代亲水和潜在亲水单体原料的优化。此外，本提案还将首次用这种方法研究多功能、响应性聚碳酸酯S的合成。这些基础研究的结合将导致几种新型共聚物在水凝胶合成中的应用，从而能够生产、表征和评估这些高度新颖的材料的性能，作为聚合物功能和结构的函数。

项目成果

Nanosponge formation from organocatalytically-synthesized poly(carbonate) copoplymers.

• DOI: 10.1021/mz300179r
• 发表时间: 2012-07-17
• 期刊: ACS macro letters
• 影响因子: 7.015
• 作者: Stevens DM;Tempelaar S;Dove AP;Harth E
• 通讯作者: Harth E

Organocatalytic synthesis and post-polymerization functionalization of propargyl-functional poly(carbonate)s

• DOI: 10.1039/c2py20718d
• 发表时间: 2013-01-01
• 期刊: POLYMER CHEMISTRY
• 影响因子: 4.6
• 作者: Tempelaar, Sarah;Barker, Ian A.;Dove, Andrew P.
• 通讯作者: Dove, Andrew P.

Benzyl bispidine as an efficient replacement for (-)-sparteine in ring opening polymerisation

• DOI: 10.1039/c2sc22053a
• 发表时间: 2013-01-01
• 期刊: CHEMICAL SCIENCE
• 影响因子: 8.4
• 作者: Todd, Richard;Rubio, Gabriel;Dove, Andrew P.
• 通讯作者: Dove, Andrew P.