HYPERANDROGENISM AND INSULIN RESISTANCE IN WOMEN
HYPERANDROGENISM AND INSULIN RESISTANCE IN WOMEN
批准号:
3325257
负责人:
Robert L Barbieri
金额:
$11.41万
依托单位国家:
美国
项目类别:
财政年份:
1990
资助国家:
美国
项目状态:
已结题
起止时间:
1990-04-01 至 1993-01-31
关键词:
androgens androstenedione female glucose metabolism graafian follicles growth factor hormone regulation /control mechanism human subject hyperglycinemia insulin insulin dependent diabetes mellitus insulin receptor insulinlike factor luteinizing hormone messenger RNA ovary somatostatin steroid hormone biosynthesis testosterone
中文摘要
卵巢雄激素过多症是最常见的一种
英文摘要
Ovarian hyperandrogenism is one of the most common
endocrinopathies of reproductive age women. Proposed etiologic
mechanisms for this common clinical syndrome include primary
abnormalities of the hypothalamic-pituitary unit, the ovary and
the adrenal gland. A unique opportunity to identify a specific
molecular cause of ovarian hyperandrogenism is provided by the
observation that hyperinsulinemia is commonly associated with
hyperandrogenism. The objective of this proposal is to test the
hypothesis that insulin and insulin-like growth factors (IGFs)
regulate ovarian androgen production and metabolism in women.
Preliminary evidence indicates that insulin, IGF-1 and LH
stimulate androgen production in incubations of minced human
ovarian stroma and theca. To further explore these effects the
following experiments are planned: 1) determination of detailed
dose-response curves for insulin, IGF-1 and LH stimulation of
thecal and stomal androgen production, 2) determination of the
effects of insulin, IGF-1 and LH on androgen production in theca
obtained from healthy or atretic follicles, 3) analysis of the
binding characteristics of insulin and IGFs to insulin receptors,
and IGF-1 receptors in ovarian theca and stroma, 4) analysis of
the effects of insulin and IGFs on specific enzymes of thecal
androgen biosynthesis (e.g. 17B - hydroxysteroid dehydrogenase),
5) use dot blots to probe ovarian tissue for the presence of mRNA
for the insulin and IGF-1 receptors.
Preliminary evidence indicated that the oral administration of 100
gms of glucose to hyperinsulinemic-hyperandrogenic women
produces an acute rise in serum androstenedione, testosterone and
dihydrotestosterone. To test the effects of insulin and glucose on
circulating androstenedione and testosterone, the following
experiments are planned: 1) examine the effects of 50 gm, 100
gm and 200 gm or oral glucose; and 25 gm and 50 gm of
intravenous glucose on circulating insulin and androgens, 2)
directly test the effects of hyperinsulinemia on circulating insulin
by using a euglycemic clamp; and 3) directly test the effects of
hyperglycemia on circulating androgens by using a hyperglycemic
clamp. These experiments should yield important information
concerning the role of metabolic factors in the regulation of
ovarian androgen production and metabolism.
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Twenty-four-hour urinary-free cortisol in premenopausal cigarette smokers and nonsmokers.
绝经前吸烟者和不吸烟者的二十四小时尿中游离皮质醇。
DOI:
10.1016/s0015-0282(16)53177-x
发表时间:
1989
期刊:
Fertility and sterility
影响因子:
6.7
作者:
[Yeh,J, Barbieri,RL]
通讯作者:
Barbieri,RL
High dietary fiber and low saturated fat intake among oligomenorrheic undergraduates.
月经稀发大学生的高膳食纤维和低饱和脂肪摄入量。
DOI:
--
发表时间:
1990
期刊:
Fertility and sterility
影响因子:
6.7
作者:
[Snow,RC, Schneider,JL, Barbieri,RL]
通讯作者:
Barbieri,RL
Rat Leydig cell and granulosa cell 17-ketosteroid reductase activity: subcellular localization and substrate specificity.
大鼠 Leydig 细胞和颗粒细胞 17-酮类固醇还原酶活性:亚细胞定位和底物特异性。
DOI:
10.1016/0002-9378(88)90595-9
发表时间:
1988
期刊:
American journal of obstetrics and gynecology
影响因子:
9.8
作者:
[Barbieri,RL, Rein,MS, Hornstein,MD, Ryan,KJ]
通讯作者:
Ryan,KJ
DOI:
10.1016/s0015-0282(16)57602-x
发表时间:
1995-06-01
期刊:
FERTILITY AND STERILITY
影响因子:
6.7
作者:
[GINSBURG, ES, WALSH, BW, BARBIERI, RL]
通讯作者:
BARBIERI, RL
Leuprolide acetate depot decreases the number of nucleolar organizer regions in uterine leiomyomata.
醋酸亮丙瑞林长效制剂可减少子宫平滑肌瘤中核仁组织区的数量。
DOI:
10.1016/s0015-0282(16)56177-9
发表时间:
1993
期刊:
Fertility and sterility
影响因子:
6.7
作者:
[Barbieri,RL, Dilena,M, Chumas,J, Rein,MS, Friedman,AJ]
通讯作者:
Friedman,AJ
共 9 条
Development of Scholars in Ob-Gyn for the 21th Century
-
批准号:6937579
-
项目类别:
-
资助金额:$14.86万
-
财政年份:1999
-
负责人:Robert L Barbieri
-
依托单位:
Development of Scholars in Ob-Gyn for the 21th Century
-
批准号:7059471
-
项目类别:
-
资助金额:$40.0万
-
财政年份:1999
-
负责人:Robert L Barbieri
-
依托单位:
DEVELOPMENT OF SCHOLARS IN OB-GYN FOR THE 21ST CENTURY
-
批准号:6689584
-
项目类别:
-
资助金额:$0.0万
-
财政年份:1999
-
负责人:Robert L Barbieri
-
依托单位:
Development of Scholars in Ob-Gyn for the 21th Century
-
批准号:7631424
-
项目类别:
-
资助金额:$40.0万
-
财政年份:1999
-
负责人:Robert L Barbieri
-
依托单位:
DEVELOPMENT OF SCHOLARS IN OB-GYN FOR THE 21ST CENTURY
-
批准号:6329782
-
项目类别:
-
资助金额:$40.0万
-
财政年份:1999
-
负责人:Robert L Barbieri
-
依托单位:
Development of Scholars in Ob-Gyn for the 21th Century
-
批准号:7243341
-
项目类别:
-
资助金额:$23.14万
-
财政年份:1999
-
负责人:Robert L Barbieri
-
依托单位:
Development of Scholars in Ob-Gyn for the 21th Century
-
批准号:7417418
-
项目类别:
-
资助金额:$23.43万
-
财政年份:1999
-
负责人:Robert L Barbieri
-
依托单位:
DEVELOPMENT OF SCHOLARS IN OB-GYN FOR THE 21ST CENTURY
-
批准号:6476582
-
项目类别:
-
资助金额:$40.0万
-
财政年份:1999
-
负责人:Robert L Barbieri
-
依托单位:
DEVELOPMENT OF SCHOLARS IN OB-GYN FOR THE 21ST CENTURY
-
批准号:6625124
-
项目类别:
-
资助金额:$40.0万
-
财政年份:1999
-
负责人:Robert L Barbieri
-
依托单位:
DEVELOPMENT OF SCHOLARS IN OB-GYN FOR THE 21ST CENTURY
-
批准号:6024024
-
项目类别:
-
资助金额:$40.0万
-
财政年份:1999
-
负责人:Robert L Barbieri
-
依托单位:
HYPERANDROGENISM AND INSULIN RESISTANCE IN WOMEN
-
批准号:3325258
-
项目类别:
-
资助金额:$4.48万
-
财政年份:1990
-
负责人:Robert L Barbieri
-
依托单位:
HYPERANDROGENISM AND INSULIN RESISTANCE IN WOMEN
-
批准号:3325255
-
项目类别:
-
资助金额:$14.32万
-
财政年份:1988
-
负责人:Robert L Barbieri
-
依托单位:
HYPERANDROGENISM AND INSULIN RESISTANCE IN WOMEN
-
批准号:3325256
-
项目类别:
-
资助金额:$9.37万
-
财政年份:1988
-
负责人:Robert L Barbieri
-
依托单位:
EFFECTS OF INSULIN AND IGFS ON OVARIAN STEROIDOGENESIS
-
批准号:3315340
-
项目类别:
-
资助金额:$15.08万
-
财政年份:1984
-
负责人:Robert L Barbieri
-
依托单位:
EFFECTS OF INSULIN AND IGFS ON OVARIAN STEROIDOGENESIS
-
批准号:3315341
-
项目类别:
-
资助金额:$13.0万
-
财政年份:1984
-
负责人:Robert L Barbieri
-
依托单位:
海外基金