Development of Scholars in Ob-Gyn for the 21th Century

21世纪妇产科学者的发展

• 批准号: 7631424
• 负责人: Robert L Barbieri
• 金额: $ 40万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-23 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7631424
• 关键词: Area; Basic Science; Biology; Development; Developmental Biology; Discipline of obstetrics; Disease; Doctor of Medicine; Doctor of Philosophy; Funding; Genetic; Gynecologic; Gynecologist; Gynecology; Hospitals; Individual; Institution; Journals; K-Series Research Career Programs; Laboratories; Malignant Neoplasms; Measures; Mentors; Minority; Ovarian; Physicians; Postdoctoral Fellow; Preventive; Qualifying; Rain; Reproductive Health; Research; Research Personnel; Running; Scientist; Time; Training; Translations; Woman; biological research; career; career development; clinical epidemiology; experience; laboratory facility; programs; reproductive; research and development; skills; square foot; tool

DESCRIPTION (provided by applicant): The objective of the Brigham and Women's Hospital (BWH) Women's Reproductive Health Research Career Development Program (the Program) is to organize and integrate the efforts of senior investigators {the Research Mentors and Academic Career Advisors) to train obstetrician-gynecologists (the Scholars) to develop into mature, broadly competent and independent investigators. Increasing the number of well-rained investigators in obstetrics and gynecology will increase the pace of translation of basic science findings into new preventive measures and treatments of women's reproductive health disorders. The BWH Program is built upon five core principles: 1) The best research development program for obstetrician-gynecologists brings together, in a single Program, both senior physician investigators and Ph.D. scientists with basic research skills. 2) Senior investigators who have independent, NIH-funded research and a record in postgraduate training are especially effective in developing Scholars into independent investigators. The BWH Program includes approximately 25 independent NIH-funded investigators, who have been involved in the training of more than 400 postdoctoral fellows, and nine Academic Career Advisors. 3) The Program must include key areas of biological research that will provide the most powerful tools to advance women's reproductive health: Reproductive Cancer, Reproductive and . Clinical Epidemiology, Reproductive Developmental Biology, Reproductive Genetics, Ovarian Biology and Urogynecology. 4) The Program must have superlative laboratory facilities, didactic training, and the commitment of the Department and institution. Research Mentors in the Program run laboratories with over 50,000 square feet of fully equipped research space and have organized seminars and journal clubs. 5) To develop Scholars who can successfully pursue an independent research career, the Program must attract the most qualified candidates and provide them with adequate time for their research experience. Scholars will be supported by matching funds, and will be guaranteed 80% research time in the Program. Scholars will have the opportunity to develop their research careers at all the Harvard-affiliated institutions including BWH, MGH and BIDMC. We believe our Program will attract a highly talented pool of individuals with the following degrees, M.D./Ph.D., M.D./M.P.H. and M.D. The Program will emphasize recruitment of women and minority Scholars. The research development program we propose will support at least three Scholars who will develop into leaders in .obstetric and gynecologic research in the 21st century.

描述（由申请人提供）：布莱根妇女医院（BWH）妇女生殖健康研究职业发展计划（该计划）的目标是组织和整合高级研究人员（研究导师和学术职业顾问）的努力，以培训妇产科医生（学者）发展成为成熟的、具有广泛能力和独立的研究人员。增加妇产科领域经验丰富的研究人员数量将加快将基础科学发现转化为妇女生殖健康疾病的新预防措施和治疗的步伐。 BWH 计划建立在五个核心原则之上： 1) 妇产科医生的最佳研究开发计划将高级医师研究人员和博士生聚集在一个计划中。具有基本研究能力的科学家。 2) 拥有 NIH 资助的独立研究和研究生培训记录的高级研究人员对于将学者培养成独立研究人员特别有效。 BWH 项目包括约 25 名由 NIH 资助的独立研究人员，他们参与了 400 多名博士后研究员的培训，以及 9 名学术职业顾问。 3) 该计划必须包括生物学研究的关键领域，这些领域将为促进妇女生殖健康提供最有力的工具：生殖癌症、生殖和。临床流行病学、生殖发育生物学、生殖遗传学、卵巢生物学和泌尿妇科。 4) 该计划必须拥有最先进的实验室设施、教学培训以及院系和机构的承诺。 该计划的研究导师运营着拥有超过 50,000 平方英尺、设备齐全的研究空间的实验室，并组织了研讨会和期刊俱乐部。 5) 为了培养能够成功从事独立研究职业的学者，该计划必须吸引最合格的候选人，并为他们提供足够的时间来积累研究经验。学者将获得配套资金支持，并保证80%的研究时间在该项目中。学者们将有机会在所有哈佛附属机构，包括 BWH、MGH 和 BIDMC 发展他们的研究生涯。我们相信我们的计划将吸引一批拥有以下学位的高素质人才：医学博士/哲学博士、医学博士/公共卫生硕士。该计划将强调招募女性和少数族裔学者。我们提出的研究发展计划将支持至少三名学者，他们将发展成为 21 世纪妇产科研究的领导者。

项目成果

Gestational carriers: A viable alternative for women with medical contraindications to pregnancy.

妊娠携带者：对于有怀孕医学禁忌症的女性来说，这是一个可行的替代方案。

• DOI: 10.4236/ojog.2013.35a2005
• 发表时间: 2013
• 期刊: Open journal of obstetrics and gynecology
• 作者: Anchan,RaymondM;Missmer,StaceyA;Correia,KatharineF;Ginsburg,ElizabethS
• 通讯作者: Ginsburg,ElizabethS

Efficient differentiation of steroidogenic and germ-like cells from epigenetically-related iPSCs derived from ovarian granulosa cells.

• DOI: 10.1371/journal.pone.0119275
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Anchan R;Gerami-Naini B;Lindsey JS;Ho JW;Kiezun A;Lipskind S;Ng N;LiCausi JA;Kim CS;Brezina P;Tuschl T;Maas R;Kearns WG;Williams Z
• 通讯作者: Williams Z

Cranial neural crest cells on the move: their roles in craniofacial development.

• DOI: 10.1002/ajmg.a.33702
• 发表时间: 2011-02
• 期刊: AMERICAN JOURNAL OF MEDICAL GENETICS PART A
• 影响因子: 2
• 作者: Cordero, Dwight R.;Brugmann, Samantha;Chu, Yvonne;Bajpai, Ruchi;Jame, Maryam;Helms, Jill A.
• 通讯作者: Helms, Jill A.

The use of angiogenic biomarkers to differentiate non-HELLP related thrombocytopenia from HELLP syndrome.

使用血管生成生物标志物区分非 HELLP 相关血小板减少症和 HELLP 综合征。

• DOI: 10.1080/14767050903184207
• 发表时间: 2010
• 期刊: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
• 作者: Young,Brett;Levine,RichardJ;Salahuddin,Saira;Qian,Cong;Lim,Kee-Hak;Karumanchi,SAnanth;Rana,Sarosh
• 通讯作者: Rana,Sarosh

First trimester vitamin D, vitamin D binding protein, and subsequent preeclampsia.

• DOI: 10.1161/hypertensionaha.110.158238
• 发表时间: 2010-10
• 期刊: Hypertension (Dallas, Tex. : 1979)
• 作者: Powe CE;Seely EW;Rana S;Bhan I;Ecker J;Karumanchi SA;Thadhani R
• 通讯作者: Thadhani R