How cholesterol optimises ion pump function in animal membranes

胆固醇如何优化动物膜中的离子泵功能

• 批准号: DP170101732
• 负责人: A/Prof Ronald Clarke
• 金额: $ 27.95万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170101732
• 关键词: How; cholesterol; optimises; ion; pump

This project aims to determine how cholesterol optimises ion pump function in animal membranes and to identify the major effects of cholesterol and its derivatives on membranes’ physical properties. All animal cells need high levels of cholesterol in the plasma membrane for survival. Insufficient cholesterol biosynthesis leads to severe birth defects. The need for cholesterol is likely linked to its acceleration of sodium pump activity, essential to physiological processes including cell division, nerve, muscle and kidney activity. An expected benefit of the project is knowledge on the molecular origin of diseases associated with inhibition of cholesterol production, and a more complete understanding of the crucial role played by cholesterol via its effect on ion pumping towards the healthy functioning of vital organs, particularly in heart muscle and nerves.

该项目旨在确定胆固醇如何优化动物膜中的离子泵功能，并确定胆固醇及其衍生物对膜物理性质的主要影响。所有动物细胞都需要质膜中高水平的胆固醇才能生存。胆固醇生物合成不足会导致严重的出生缺陷。对胆固醇的需求可能与其钠泵活动的加速有关，钠泵活动是包括细胞分裂、神经、肌肉和肾脏活动在内的生理过程所必需的。该项目的预期好处是了解与抑制胆固醇生成有关的疾病的分子起源，并更全面地了解胆固醇通过其对离子泵的影响而发挥的关键作用，从而促进重要器官，特别是心脏、肌肉和神经的健康功能。