SURGICAL ASPECT OF SHOCK AND HYPOXIA
SURGICAL ASPECT OF SHOCK AND HYPOXIA
批准号:
3335888
负责人:
IRSHAD H CHAUDRY
金额:
$39.3万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1977
资助国家:
美国
项目状态:
已结题
起止时间:
1977-02-01 至 1986-07-31
关键词:
adenosine triphosphate bactericidal immunity burns calcium metabolism cardiovascular disorder chemotherapy cardiovascular surgery cell components cell membrane cellular immunity cerebral ischemia /hypoxia cyclophosphamide electron microscopy epinephrine freeze etching gamma globulin heart function heart revascularization hemorrhagic shock high energy compound humoral immunity hypoxia immunoregulation ion transport liver liver metabolism magnesium membrane permeability membrane potentials membrane structure muscle metabolism myocardial ischemia /hypoxia nicotinamide nutrition related tag peptides peritonitis phosphates potassium prostaglandins pulmonary edema radioimmunoassay renal ischemia /hypoxia shock smooth muscle sodium splenectomy suppressor T lymphocyte thyroid function tissue /cell culture
中文摘要
这项建议的主旨是继续我们在各个方面的工作
休克和缺氧的各个方面,这对
喜欢冲浪的病人。我们对细胞和细胞变化的普里沃伊斯观察
休克后的亚细胞功能和其中的一些纠正
职能将作为我们现在计划确定的基础:a)
体液因素在产生这种变化中所起的作用;b)
这种变化的相互关系,也许是相互依存,
细胞能量学和膜功能;c)原因
对于器官衰竭,部分肌肉和肝脏细胞代谢和
晚期败血症和多系统衰竭的线粒体衰竭;d)
败血症并发远隔器官衰竭的顺序和原因;e)
烧伤后免疫功能低下的原因;以及f)进一步
旨在改善细胞功能的治疗考虑和
实现这一点的机制。具体活动领域包括:1)角色
肾上腺素在产生肝脏去极化、代谢方面起作用
抑制、胰岛素抵抗与膜通透性的变化
2)评价甲状腺在晚期脓毒症中的作用。
器官衰竭与“粘液水肿性线粒体”的可能性
肌肉和肝脏的终末性代谢衰竭;3)进一步研究
高能磷酸盐产生有益物质的精确机制
作用;4)腺嘌呤的表征、动力学和定位
细胞内核苷酸摄取和潜在转运的测定
载体系统;5)进一步研究以确定临界能级
细胞功能的各个方面;6)必要的背景信息
三磷酸腺苷-氯化镁的临床试验;7)低钙血症的钙调节状况
血流状态;8)肝脏代谢改变的性质
脓毒症的能力;9)术后肾脏保存的研究
常温缺血;10)无论是磷酸肌酸还是其他底物
将有助于预防冠状动脉病变期间心脏的缺血性损害
在急性呼吸衰竭期间和之后对中枢神经系统的影响
缺血性损伤;11)Tuftsin增加肺内滞留的研究
脾切除和脓毒症后的颗粒物;以及
包括去除抑制性T细胞前体的治疗将
提高烧伤后的抗感染能力。
英文摘要
The major thrust of this proposal is to continue our work on various
aspects of shock and hypoxia, which are of particular importance for the
surfical patient. Our prevoius observations of changes in cellular and
sub-cellular functions following shock and correction of some of those
functions will serve as the basis on which we now plan to determine: a)
the role humoral factors play in producing such changes; b) the
interrelationships and perhaps interdependence of such changes,
parricularly of cellular energetics and membrane function; c) the reason
for organ failure, partucularly muscle and liver cellular metabolic and
mitochondrial failure in late sepsis and with multiple systems failure; d)
the sequences of and reasons for remote organ failure with sepsis; e) the
reason for depressed immunocompetence following burn trauma; and f) further
therapeutic considerations aimed at improving cell function and the
mechanisms for this. Specific areas of activity include: 1) the role
epinephrine plays in producing hepatic depolarization, metabolic
depression, insluin resistance and alterations in membrane permeabilityu
with shock; 2) evaluation of the role of the thyroid in late sepsis and
organ failure and the possibility of "myxedematous mitochondria" causing
the terminal metabolic failure of muscle and liver; 3) further study of the
precise mechanism by which high energy phosphate compounds produce salutary
effects; 4) characterization, kinetics and localization of adenine
nucleotide uptake in the cell and determination of a potential transport
carrier system; 5) further studies to determine critical energy levels for
various aspects of cell function; 6) necessary background information for
clinical trials of ATP-MgC12; 7) the status of calcium regulation in low
flow conditions; 8) the nature of alterations in hepatic metabolic
capabilities in sepsis; 9) study of kidney preservation following
normothermic ischemia; 10) whether creatine phosphate or other substrates
will help prevent ischemic damage to the heart during coronary
insufficiency and to the central nervous system during and after an acute
ischemic insult; 11) study of tuftsin on increased pulmonary retention of
particulate matter following splenectomy and sepsis; and 12) whether
therapy involving ablations of precursors of suppressor-T cells would
improve the resistance to infection following burn injury.
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Improved renal function using adenosine triphosphate-magnesium chloride in preservation of canine kidneys subjected to warm ischemia.
使用三磷酸腺苷-氯化镁保存遭受热缺血的犬肾可改善肾功能。
DOI:
10.1097/00007890-198103000-00009
发表时间:
1981
期刊:
Transplantation
影响因子:
6.2
作者:
[Lytton,B, Vaisbort,VR, Glazier,WB, Chaudry,IH, Baue,AE]
通讯作者:
Baue,AE
Effect of prolonged starvation on reticuloendothelial function and survival following trauma.
长期饥饿对网状内皮功能和创伤后生存的影响。
DOI:
10.1097/00005373-198108000-00003
发表时间:
1981
期刊:
The Journal of trauma
影响因子:
--
作者:
[Chaudry,IH, Schleck,S, Kovacs,KF, Baue,AE]
通讯作者:
Baue,AE
Studies on the mechanism of beneficial effects of ATP-MgCl2 following hepatic ischemia.
肝缺血后 ATP-MgCl2 有益作用机制的研究。
DOI:
10.1152/ajpregu.1983.244.5.r695
发表时间:
1983
期刊:
The American journal of physiology
影响因子:
--
作者:
[Ohkawa,M, Clemens,MG, Chaudry,IH]
通讯作者:
Chaudry,IH
Does ATP cross the cell plasma membrane.
ATP 是否穿过细胞质膜。
DOI:
--
发表时间:
1982
期刊:
The Yale journal of biology and medicine
影响因子:
--
作者:
[Chaudry,IH]
通讯作者:
Chaudry,IH
Red blood cell sodium, potassium, and ATP levels during hemorrhagic shock.
失血性休克期间红细胞钠、钾和 ATP 水平。
DOI:
10.1016/0022-4804(81)90225-0
发表时间:
1981
期刊:
The Journal of surgical research
影响因子:
--
作者:
[KreisJr,DJ, Chaudry,IH, Schleck,S, Baue,AE]
通讯作者:
Baue,AE
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