SURGICAL ASPECT OF SHOCK AND HYPOXIA

这项建议的主旨是继续我们在各个方面的工作 休克和缺氧的各个方面，这对 喜欢冲浪的病人。我们对细胞和细胞变化的普里沃伊斯观察 休克后的亚细胞功能和其中的一些纠正 职能将作为我们现在计划确定的基础：a) 体液因素在产生这种变化中所起的作用；b) 这种变化的相互关系，也许是相互依存， 细胞能量学和膜功能；c)原因 对于器官衰竭，部分肌肉和肝脏细胞代谢和 晚期败血症和多系统衰竭的线粒体衰竭；d) 败血症并发远隔器官衰竭的顺序和原因；e) 烧伤后免疫功能低下的原因；以及f)进一步 旨在改善细胞功能的治疗考虑和 实现这一点的机制。具体活动领域包括：1)角色 肾上腺素在产生肝脏去极化、代谢方面起作用 抑制、胰岛素抵抗与膜通透性的变化 2)评价甲状腺在晚期脓毒症中的作用。 器官衰竭与“粘液水肿性线粒体”的可能性 肌肉和肝脏的终末性代谢衰竭；3)进一步研究 高能磷酸盐产生有益物质的精确机制 作用；4)腺嘌呤的表征、动力学和定位 细胞内核苷酸摄取和潜在转运的测定 载体系统；5)进一步研究以确定临界能级 细胞功能的各个方面；6)必要的背景信息 三磷酸腺苷-氯化镁的临床试验；7)低钙血症的钙调节状况 血流状态；8)肝脏代谢改变的性质 脓毒症的能力；9)术后肾脏保存的研究 常温缺血；10)无论是磷酸肌酸还是其他底物 将有助于预防冠状动脉病变期间心脏的缺血性损害 在急性呼吸衰竭期间和之后对中枢神经系统的影响 缺血性损伤；11)Tuftsin增加肺内滞留的研究 脾切除和脓毒症后的颗粒物；以及 包括去除抑制性T细胞前体的治疗将 提高烧伤后的抗感染能力。

The major thrust of this proposal is to continue our work on various aspects of shock and hypoxia, which are of particular importance for the surfical patient. Our prevoius observations of changes in cellular and sub-cellular functions following shock and correction of some of those functions will serve as the basis on which we now plan to determine: a) the role humoral factors play in producing such changes; b) the interrelationships and perhaps interdependence of such changes, parricularly of cellular energetics and membrane function; c) the reason for organ failure, partucularly muscle and liver cellular metabolic and mitochondrial failure in late sepsis and with multiple systems failure; d) the sequences of and reasons for remote organ failure with sepsis; e) the reason for depressed immunocompetence following burn trauma; and f) further therapeutic considerations aimed at improving cell function and the mechanisms for this. Specific areas of activity include: 1) the role epinephrine plays in producing hepatic depolarization, metabolic depression, insluin resistance and alterations in membrane permeabilityu with shock; 2) evaluation of the role of the thyroid in late sepsis and organ failure and the possibility of "myxedematous mitochondria" causing the terminal metabolic failure of muscle and liver; 3) further study of the precise mechanism by which high energy phosphate compounds produce salutary effects; 4) characterization, kinetics and localization of adenine nucleotide uptake in the cell and determination of a potential transport carrier system; 5) further studies to determine critical energy levels for various aspects of cell function; 6) necessary background information for clinical trials of ATP-MgC12; 7) the status of calcium regulation in low flow conditions; 8) the nature of alterations in hepatic metabolic capabilities in sepsis; 9) study of kidney preservation following normothermic ischemia; 10) whether creatine phosphate or other substrates will help prevent ischemic damage to the heart during coronary insufficiency and to the central nervous system during and after an acute ischemic insult; 11) study of tuftsin on increased pulmonary retention of particulate matter following splenectomy and sepsis; and 12) whether therapy involving ablations of precursors of suppressor-T cells would improve the resistance to infection following burn injury.