SYNTHESIS OF CARDIOVASCULAR POLYETHER ANTIBIOTICS

心血管聚醚抗生素的合成

• 批准号: 3338154
• 负责人: WILLIAM C STILL
• 金额: $ 24.07万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-04-01 至 1988-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3338154
• 关键词: Streptomyces; antibiotics; antiinfective agents; cardiovascular agents; chelating agents; chemical structure function; computer simulation; conformation; drug design /synthesis /production; drug screening /evaluation; ethers; ionophores; ketones; mathematical model; stereochemistry

The purpose of our work is to develop new methodology for the synthesis of biologically active polyether antibiotics. The work proposed involves the chelation-directed addition of organometallics to alkoxycarbonyl compounds and macrocyclically-directed remote asymmetric induction. Such methodology is being applied to the total synthesis of the polyether antibiotics monensin and lysocellin.

我们工作的目的是开发新的方法学来合成 具有生物活性的聚醚抗生素。建议的工作涉及 有机金属与烷氧基化合物的络合定向加成反应 宏观周期导向的远程不对称诱导。这种方法论正在被 应用于聚醚类抗生素莫能菌素的全合成 Lyocellin。