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SYNTHESIS OF CARDIOVASCULAR POLYETHER ANTIBIOTICS

SYNTHESIS OF CARDIOVASCULAR POLYETHER ANTIBIOTICS
心血管聚醚抗生素的合成
批准号：
3338152
负责人：
WILLIAM C STILL
金额：
$22.0万
依托单位：
COLUMBIA UNIV NEW YORK MORNINGSIDE
依托单位国家：
美国
项目类别：
财政年份：
1980
资助国家：
美国
项目状态：
已结题
起止时间：
1980-04-01 至 1988-03-31
来源：
https://reporter.nih.gov/project-details/3338152
关键词：
Streptomyces antibiotics antiinfective agents cardiovascular agents chelating agents chemical structure function computer simulation conformation drug design /synthesis /production drug screening /evaluation ethers ionophores ketones mathematical model stereochemistry

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中文摘要
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英文摘要
The purpose of our work is to develop new methodology for the synthesis of biologically active polyether antibiotics. The work proposed involves the chelation-directed addition of organometallics to alkoxycarbonyl compounds and macrocyclically-directed remote asymmetric induction. Such methodology is being applied to the total synthesis of the polyether antibiotics monensin and lysocellin.
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