The Logistics of Small Things - A Crossdisciplinary Feasibility Account

小物品的物流——跨学科的可行性分析

• 批准号: EP/H024905/1
• 负责人: Natalio Krasnogor
• 金额: $ 25.74万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FH024905%2F1
• 关键词: Logistics; Small; Things; Crossdisciplinary; Feasibility

Nottingham's leading edge research at the interface of Computer Science and Operational Research (OR) is concerned with developing decision support systems for the optimal handling of large numbers (~ millions) of macroscopic objects, e.g., truck delivery, personnel rostering, space allocation, runway scheduling, etc. Nano and Bio sciences, on the other hand, deal with billions (or more) of micro/nano-scale objects. Very little research has been done on trying to bridge the gap between OR and NanoBio technologies for which scale reductions bring an explotion in objects' quantities. The Logistics of Small Things will be the conceptual umbrella under which the following research themes (and others) will be investigated:* Accelerating Nanoscience: Scanning Probe Microscopy is used to image and manipulate atom-sized objects. This process, a key-enabling technology for the nanosciences, is extremely laborious and time consuming. Can OR & decision support methodologies be brought to bear at the atom level? Can state-of-the-art planning and scheduling technologies be altered and developed to optimally build, atom-by-atom, complex matter? * Smart Drugs Automated Programming: Future smart drugs will be, at their core, distributed (nano-bio) information processing devices. Splitting up complex decision-making tasks (e.g. a given nano-capsule attaches to a specific cell, delivers its drug payload, monitors and reports progress) into myriads of simpler molecular processes is a critical bottleneck in patient-specific nanomedicine. Can decision support systems derived from, e.g., Genetic Programming, be used to automatically and optimally program Smart Drugs? * Optimising the life-cycle of Synthetic Biology Projects: Synthetic Biology aims at operating within an Engineering-like ethos. However, current practice lacks a rigorous and formal decision making process. That is, questions such as what is the most cost-effective path from design to implementation for a synthetic biology project? have no framework from where they could be systematically studied and answered. Can one define a Synthetic Biology project's life-cycle to minimise its costs?The Logistics of Small Things Cross-Disciplinary Feasibility account will seek to probe the interface between OR and the NanoBio Sciences. If the latter are to deliver practical applications soon, several logistics bottlenecks will need to be removed. This project will seek to identify where those bottlenecks reside and prototype their solutions

诺丁汉在计算机科学和运筹学（OR）接口的前沿研究涉及开发决策支持系统，用于优化处理大量（~数百万）宏观对象，例如，另一方面，纳米和生物科学处理数十亿（或更多）微米/纳米尺度的物体。很少有研究试图弥合OR和NanoBio技术之间的差距，因为缩小规模会带来物体数量的爆炸。小东西的物流将是概念伞下，以下研究主题（和其他）将被调查：* 加速纳米科学：扫描探针显微镜用于成像和操纵原子大小的物体。这个过程是纳米科学的关键技术，非常费力和耗时。OR和决策支持方法能在原子级上发挥作用吗？最先进的计划和调度技术是否可以改变和发展，以最佳方式逐个原子地构建复杂的物质？* 智能药物自动编程：未来智能药物的核心将是分布式（纳米生物）信息处理设备。将复杂的决策任务（例如，给定的纳米胶囊附着在特定的细胞上，提供其药物有效载荷，监测和报告进展）分解为无数简单的分子过程是患者特异性纳米医学的关键瓶颈。决策支持系统是否可以从，例如，基因编程，用于自动和最佳编程智能药物？* 优化合成生物学项目的生命周期：合成生物学旨在以类似工程的精神运作。然而，目前的做法缺乏严格和正式的决策过程。也就是说，问题，如什么是最具成本效益的路径，从设计到实施的合成生物学项目？没有一个可以系统地研究和回答这些问题的框架。可以定义一个合成生物学项目的生命周期，以尽量减少其成本？小东西的物流跨学科的可行性帐户将寻求探索OR和纳米生物科学之间的接口。如果后者要很快交付实际应用，就需要消除几个物流瓶颈。该项目将寻求确定这些瓶颈所在，并制定解决方案的原型

项目成果

First principles predictions of thermophysical properties of refrigerant mixtures.

制冷剂混合物热物理性质的第一原理预测。

• DOI: 10.1063/1.3567308
• 发表时间: 2011
• 期刊: The Journal of chemical physics
• 作者: Oakley MT

Photochromic molecular implementations of universal computation.

通用计算的光致变色分子实现。

• DOI: 10.1016/j.biosystems.2014.09.004
• 发表时间: 2014
• 期刊: Bio Systems
• 作者: Chaplin JC

, Simulation Modelling of Nanoparticle Assemblies Formed by Spray Deposition

, 喷雾沉积形成的纳米颗粒组件的模拟建模

• 发表时间: 2011
• 作者: T. Maul

Simulation modelling study of self-assembled nanoparticle coatings for retinal implants

视网膜植入物自组装纳米粒子涂层的模拟建模研究

• DOI: 10.1016/s1672-6529(13)60200-0
• 发表时间: 2013
• 期刊: Journal of Bionic Engineering
• 影响因子: 4
• 作者: Maul T