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Bacteriophage and Antibiotic Resistance: a Mathematical and Imaging Approach (C-DIP enhancement)

噬菌体和抗生素耐药性：数学和成像方法（C-DIP 增强）

基本信息

批准号：
EP/I018263/1
负责人：
Robert Beardmore
金额：
$ 10.67万
依托单位：
UNIVERSITY OF EXETER
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2010
资助国家：
英国
起止时间：
2010 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FI018263%2F1
关键词：
Bacteriophage Antibiotic Resistance Mathematical Imaging

项目摘要

While scientific research was usually conducted in centuries past by loan, gentleman scientists,modern research is different. It needs people with different skills and different scientific trainingto come together with a common vision to solve a common problem.Think of a large task, like building a plane. It needs control engineers, material scientists,software engineers, fluid dynamicists, test pilots, to name but a few of the types of peoplewho might be involved. Ask yourself, how does a software engineer with a training in thedevelopment of programming languages, say, talk to a metallurgist or chemist in order tosolve the problems they encounter on a daily basis in the aeronautical industries?Of course, in industrial contexts one answer lies in training as the path to constructing a planeis largely known. But in science, there are no well-developed training programmes that allowpeople to come together to solve the big problems, we might not even know what people toput together in order to solve them. So, we need patience, lots of it, and trust but we also need funding and helpwith the process of getting ideas from one field to permeate into another.Often, as a mathematician, when I express my ideas to biologist colleagues, they first tell methat I am mad, that I must be wrong because there are experimental results from decadespast that contradict my thinking. However, over time, with enough coffee and patience we canexplore each others viewpoint and crystalise and then distill the idea down to its bare minimum. We thensee whether there really is something that mathematical thinking can bring to biology, or to physicsor chemistry.This can be a personal and painful process, but it is worthwhile in that the amalgam of two sets of ideaslead to new independent thinking and new ideas. However, this is not a route or an approach commonly funded by research councils. In this case EPSRC have been explicit in their desire for research themes that aimto bridge these gaps between disciplines and to really foster avenues of communication where few ornone currently exist. The funding associated with this award will be put to good use to create alively and relaxed research environment where we can express our mad ideas and see if they can beput to good use to solve important problems in a range of fields that spans physics, biology and mathematics.If the recent past is a guide to the near future, we expect this endeavour will lead to a number of new and important scientific insights.

虽然科学研究在过去的几个世纪里通常是通过贷款进行的，绅士科学家，现代研究是不同的。它需要拥有不同技能和不同科学训练的人，带着共同的愿景走到一起，解决一个共同的问题。想想一个大的任务，比如造一架飞机。它需要控制工程师，材料科学家，软件工程师，流体动力学家，试飞员，仅举几个可能参与的人的例子。问问你自己，一个受过编程语言开发培训的软件工程师，比如说，如何与一个计算机专家或化学家交谈，以解决他们在航空工业中每天遇到的问题？当然，在工业背景下，一个答案在于培训，因为建造飞机的途径基本上是众所周知的。但是在科学领域，没有完善的培训计划让人们聚集在一起解决大问题，我们甚至不知道人们为了解决问题应该在一起做些什么。所以，我们需要耐心，很多耐心，和信任，但我们也需要资金和帮助，帮助我们将一个领域的想法渗透到另一个领域。通常，作为一个数学家，当我向生物学家的同事表达我的想法时，他们首先告诉我，我疯了，我一定是错了，因为几十年前的实验结果与我的想法相矛盾。然而，随着时间的推移，有了足够的咖啡和耐心，我们可以探索彼此的观点，然后将想法提炼到最低限度。然后，我们会看到数学思维是否真的能给生物学、物理学或化学带来什么。这可能是一个个人的痛苦过程，但它是值得的，因为这两套思想的融合会带来新的独立思考和新的想法。然而，这不是研究委员会通常资助的路线或方法。在这种情况下，EPSRC明确表示他们希望研究主题旨在弥合学科之间的这些差距，并真正促进目前很少或根本不存在的交流途径。与此奖项相关的资金将被很好地用于创造活跃和宽松的研究环境，在那里我们可以表达我们的疯狂想法，看看他们是否可以很好地利用来解决跨越物理学，生物学和数学的一系列领域的重要问题。如果最近的过去是一个指导不久的将来，我们预计这一努力将导致一些新的和重要的科学见解。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Biophysical mechanisms that maintain biodiversity through trade-offs.

通过权衡维持生物多样性的生物物理机制。

DOI：
10.1038/ncomms7278
发表时间：
2015
期刊：
Nature communications
影响因子：
16.6
作者：
Meyer JR
通讯作者：
Meyer JR

Using a sequential regimen to eliminate bacteria at sublethal antibiotic dosages.

DOI：
10.1371/journal.pbio.1002104
发表时间：
2015-04
期刊：
PLoS biology
影响因子：
9.8
作者：
Fuentes-Hernandez A;Plucain J;Gori F;Pena-Miller R;Reding C;Jansen G;Schulenburg H;Gudelj I;Beardmore R
通讯作者：
Beardmore R

Modelling cognitive decline in the Hypertension in the Very Elderly Trial [HYVET] and proposed risk tables for population use.

对老年高血压试验 [HYVET] 中的认知能力下降进行建模，并提出供人群使用的风险表。