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Encapsulated phage for treatment of burns and wound site infections

用于治疗烧伤和伤口部位感染的封装噬菌体

基本信息

批准号：
EP/I027602/1
负责人：
Andrew Tobias Aveling Jenkins
金额：
$ 83.84万
依托单位：
University of Bath
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2011
资助国家：
英国
起止时间：
2011 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FI027602%2F1
关键词：
Encapsulated phage treatment burns wound

项目摘要

This project, in partnership with Biocontrol Ltd and the departments of Chemistry and Chemical Engineering at the University of Bath, will encapsulate specific lytic phages within phospholipid vesicles, and incorporate the vesicles into a prototype burn / wound dressing and a topical aqueous cream. The primary focus of the work is in the prevention of infection of paediatric burns, where our clinical partner, Dr Amber Young at the South West Paediatric Burns Centre, Frenchay hospital will provide expertise. The vesicles will be designed such that they both will stabilize the phage over time i.e. when stored, but only release their contents following exposure to secreted toxins and enzymes from pathogenic bacteria. The aim of this project is to reduce the risk of infection from burns and other injuries by making a 'smart' dressing, based on phage therapeutics.38,000 children on average suffer burn injuries in England and Wales each year, of which 55% are scalds. Most are small in area, 80% are in children under five years and the majority are due to hot drink spillages. One of the primary problems in the treatment of burns is bacterial infection, which can delay healing, increase pain; increase the risk of scarring and in some cases cause death. In recent years there have been great improvements in the treatment of burns, particularly with biologically-derived dressings which actively promote cell growth. However, the problem of infection has not gone away, and there is evidence that silver treated antimicrobial dressings can delay burn healing.

该项目与生物控制有限公司和巴斯大学化学与化学工程系合作，将在磷脂囊泡内封装特定的溶解性磷脂，并将囊泡纳入原型烧伤/伤口敷料和局部水性乳膏中。这项工作的主要重点是预防儿科烧伤感染，我们的临床合作伙伴，弗伦谢医院西南儿科烧伤中心的Amber Young博士将提供专业知识。囊泡将被设计成使得它们都将随时间稳定噬菌体，即当储存时，但仅在暴露于来自病原性细菌的分泌毒素和酶之后释放它们的内容物。该项目的目的是通过制造基于噬菌体疗法的“智能”敷料来降低烧伤和其他伤害的感染风险。英格兰和威尔士每年平均有38，000名儿童遭受烧伤，其中55%是烫伤。大多数是小面积，80%是五岁以下的儿童，大多数是由于热饮溢出。烧伤治疗中的主要问题之一是细菌感染，这会延迟愈合，增加疼痛;增加瘢痕形成的风险，并在某些情况下导致死亡。近年来，烧伤的治疗有了很大的改进，特别是生物衍生的敷料，它能积极促进细胞生长。然而，感染的问题并没有消失，有证据表明，银处理的抗菌敷料可以延迟烧伤愈合。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Triggered Release of Bacteriophage K from Agarose/Hyaluronan Hydrogel Matrixes by Staphylococcus aureus Virulence Factors

DOI：
10.1021/cm503974g
发表时间：
2014-12-23
期刊：
CHEMISTRY OF MATERIALS
影响因子：
8.6
作者：
Bean, Jessica E.;Alves, Diana R.;Jenkins, A. Toby A.
通讯作者：
Jenkins, A. Toby A.

A novel bacteriophage cocktail reduces and disperses Pseudomonas aeruginosa biofilms under static and flow conditions.

DOI：
10.1111/1751-7915.12316
发表时间：
2016-01
期刊：
Microbial biotechnology
影响因子：
5.7
作者：
Alves DR;Perez-Esteban P;Kot W;Bean JE;Arnot T;Hansen LH;Enright MC;Jenkins AT
通讯作者：
Jenkins AT

Enhancement of the antimicrobial properties of bacteriophage-K via stabilization using oil-in-water nano-emulsions.

通过使用水包油纳米乳液进行稳定化增强噬菌体-K 的抗菌特性。