Development of an infection detecting wound dressing

开发感染检测伤口敷料

基本信息

  • 批准号:
    MR/N006496/1
  • 负责人:
  • 金额:
    $ 114.97万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2015
  • 资助国家:
    英国
  • 起止时间:
    2015 至 无数据
  • 项目状态:
    已结题

项目摘要

Infection is the primary cause of complications following a burn injury. Even a small hot water scalds can become infected, which can lead to a great increase in pain, delayed healing, increased scarring, and a greater time in treatment (including antibiotic usage and surgery). This not only undermines the outcome for patients, but also increases costs to the NHS related to treatment, but also patients, in terms of days off work, travel to hospital, and related loss of income. In rare cases infection can lead to death, particularly in large and deep burns and even in children with small burns, via complications such as toxic shock syndrome. Despite the importance of identifying infection, this currently remains a major challenge for clinicians. Much of the difficulty arises from the fact that the symptoms of infection in burn patients can be very difficult to distinguish from other symptoms arising from inflammatory response to the burn itself, as well as other illness such as cold, sore throat etc. Because of these challenges, the standard methods that clinicians use to diagnose infection under other conditions are of limited value in treating burns patients. The situation is further complicated by the fact that most wounds have normal background level of bacteria, which does not need to be treated unless bacteria reach a certain level at which they begin to cause harm. However, clinicians may wait ~3 days to confirm the presence of bacteria in a wound, but these tests do not distinguish between beginning background levels and those representative of infection. Collectively, these limitations can also lead to patients being 'over treated', resulting in over and unnecessary prescription of antibiotics, dressing changes (which are often painful and may increase the risk of scarring), and extended hospital stay. The dressing being developed in this research programme indicates critical bacterial infection within a burn wound without the need to remove it. The dressing will signal infection by a simple colour change, that occurs when clinically relevant bacteria in the wound reach a level at which treatment is necessary. This can be used by clinicians directly at the patients bedside to provide more accurate and more effective treatment. In doing so our technology would not only improve outcomes for patients, but also reduce NHS costs and unnecessary antibiotic use.
感染是烧伤后并发症的主要原因。即使是很小的热水烫伤也可能被感染,这可能会导致疼痛大大增加,愈合延迟,增加疤痕,以及更长的治疗时间(包括抗生素的使用和手术)。这不仅破坏了患者的结果,还增加了NHS与治疗相关的成本,而且还增加了患者的休假天数、去医院的旅行和相关的收入损失。在极少数情况下,感染可通过中毒性休克综合征等并发症导致死亡,特别是在大面积和深度烧伤,甚至是小面积烧伤的儿童。尽管识别感染很重要,但这目前仍然是临床医生面临的一大挑战。许多困难是因为烧伤患者的感染症状很难与烧伤本身的炎症反应以及感冒、喉咙痛等其他疾病引起的其他症状区分开来。由于这些挑战,临床医生在其他情况下诊断感染的标准方法在治疗烧伤患者方面的价值有限。大多数伤口的细菌本底水平正常,除非细菌达到一定水平,开始造成伤害,否则不需要治疗,这让情况变得更加复杂。然而,临床医生可能要等3天才能确认伤口中是否存在细菌,但这些测试不能区分初始本底水平和代表感染的水平。总体而言,这些限制还可能导致患者被过度治疗,导致过度和不必要的抗生素处方,换药(这通常是痛苦的,可能会增加疤痕的风险),以及延长住院时间。这项研究计划正在开发的敷料表明烧伤创面内的严重细菌感染,而不需要移除它。敷料将通过简单的颜色变化来发出感染的信号,当伤口中的临床相关细菌达到需要治疗的水平时就会发生。这可供临床医生直接在患者床边使用,提供更准确、更有效的治疗。通过这样做,我们的技术不仅将改善患者的预后,还将减少NHS的成本和不必要的抗生素使用。

项目成果

期刊论文数量(9)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Development of an Infection-Responsive Fluorescent Sensor for the Early Detection of Urinary Catheter Blockage.
  • DOI:
    10.1021/acssensors.7b00861
  • 发表时间:
    2018-02
  • 期刊:
  • 影响因子:
    8.9
  • 作者:
    Scarlet Milo;Florianne B. Acosta;H. Hathaway;Laura A Wallace;N. Thet;A. Jenkins
  • 通讯作者:
    Scarlet Milo;Florianne B. Acosta;H. Hathaway;Laura A Wallace;N. Thet;A. Jenkins
Variation in definitions of burn wound infection limits the validity of systematic review findings in burn care: A systematic review of systematic reviews
烧伤创面感染定义的变化限制了烧伤护理系统评价结果的有效性:系统评价的系统评价
  • DOI:
    10.1016/j.burns.2021.05.006
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    2.7
  • 作者:
    Lee K
  • 通讯作者:
    Lee K
Fluoxetine and thioridazine inhibit efflux and attenuate crystalline biofilm formation by Proteus mirabilis.
氟西汀和硫利达嗪抑制奇异变形杆菌的外流并减弱结晶生物膜的形成。
  • DOI:
    10.1038/s41598-017-12445-w
  • 发表时间:
    2017-09-22
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
    Nzakizwanayo J;Scavone P;Jamshidi S;Hawthorne JA;Pelling H;Dedi C;Salvage JP;Hind CK;Guppy FM;Barnes LM;Patel BA;Rahman KM;Sutton MJ;Jones BV
  • 通讯作者:
    Jones BV
Development of a High-Throughput ex-Vivo Burn Wound Model Using Porcine Skin, and Its Application to Evaluate New Approaches to Control Wound Infection.
  • DOI:
    10.3389/fcimb.2018.00196
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    5.7
  • 作者:
    Alves DR;Booth SP;Scavone P;Schellenberger P;Salvage J;Dedi C;Thet NT;Jenkins ATA;Waters R;Ng KW;Overall ADJ;Metcalfe AD;Nzakizwanayo J;Jones BV
  • 通讯作者:
    Jones BV
Consensus demonstrates four indicators needed to standardize burn wound infection reporting across trials in a single-country study (ICon-B study)
  • DOI:
    10.1016/j.jhin.2020.07.022
  • 发表时间:
    2020-10-01
  • 期刊:
  • 影响因子:
    6.9
  • 作者:
    Davies, A.;Teare, L.;Young, A.
  • 通讯作者:
    Young, A.
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Andrew Tobias Aveling Jenkins其他文献

Andrew Tobias Aveling Jenkins的其他文献

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{{ truncateString('Andrew Tobias Aveling Jenkins', 18)}}的其他基金

Plasma-activated antimicrobial hydrogel therapy (PAHT) for combating infections in diabetic foot ulcers
等离子体激活抗菌水凝胶疗法 (PAHT) 用于对抗糖尿病足溃疡感染
  • 批准号:
    EP/V00462X/1
  • 财政年份:
    2021
  • 资助金额:
    $ 114.97万
  • 项目类别:
    Research Grant
Smartwound-plasma
Smartwound-等离子
  • 批准号:
    EP/R003939/1
  • 财政年份:
    2017
  • 资助金额:
    $ 114.97万
  • 项目类别:
    Research Grant
Encapsulated phage for treatment of burns and wound site infections
用于治疗烧伤和伤口部位感染的封装噬菌体
  • 批准号:
    EP/I027602/1
  • 财政年份:
    2011
  • 资助金额:
    $ 114.97万
  • 项目类别:
    Research Grant

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