SMART-Endomicroscopy (Sensing and Mechatronically Assisted Real-Time Endomicroscopy)

SMART-内镜检查（传感和机电辅助实时内镜检查）

• 批准号: EP/I027769/1
• 负责人: Guang-Zhong Yang
• 金额: $ 126.95万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FI027769%2F1
• 关键词: SMART; Endomicroscopy; Sensing; Mechatronically; Assisted

As surgical techniques become more minimally invasive, there is an inevitable increase in complexity of the operating platforms. Clinically, it is of vital importance to integrate real-time microscopic visualisation into the surgical workflow in a seamless way and in combination with the existing imaging modalities such as MRI, CT and ultrasound. The aim of this proposal is to develop a new SMART-endomicroscopic probe that integrates in situ sensing and mechatronic control to allow for flexible and consistent tissue characterisation for Minimally Invasive Surgery (MIS). It addresses specific research and engineering challenges related to biophotonics, mechanical/optical miniaturisation and integration, super-resolution image reconstruction, as well as tracking, localisation and large area coverage for in vivo, in situ tissue characterisation. Through multi-scale minimally invasive imaging integration, the proposed SMART-Endomicroscope will potentially allow cancer staging and intervention to be performed as a single procedure, permitting histological and vascular examination to be performed at all stages of the operation, such that management decisions can be altered intra-operatively to ensure best treatment for the individual patient. This will help to transform surgical treatment options and patient cancer outcomes as personalised healthcare becomes a reality. The project echoes the current paradigm shift in MIS towards miniaturised smart instruments with integrated imaging and sensing, enhanced by robotic control. It is supported by a multidisciplinary team with complementary skills in physics, engineering, medical image computing and surgery.

随着手术技术越来越微创化，手术平台的复杂性也不可避免地增加。在临床上，将实时显微可视化与现有的成像方式（如MRI、CT和超声）无缝整合到手术工作流程中至关重要。本提案的目的是开发一种新的智能内窥镜探头，集成了原位传感和机电控制，以便为微创手术（MIS）提供灵活和一致的组织表征。它解决了与生物光子学，机械/光学小型化和集成，超分辨率图像重建以及体内原位组织表征的跟踪，定位和大面积覆盖相关的特定研究和工程挑战。通过多尺度微创成像集成，提出的SMART-Endomicroscope将有可能使癌症分期和干预作为一个单一的程序进行，允许在手术的所有阶段进行组织学和血管检查，这样可以在术中改变管理决策，以确保对个体患者进行最佳治疗。随着个性化医疗保健成为现实，这将有助于改变手术治疗选择和患者癌症结果。该项目呼应了当前MIS向集成成像和传感的小型化智能仪器的转变，并通过机器人控制得到增强。它由一个多学科团队提供支持，该团队在物理、工程、医学图像计算和外科方面具有互补技能。

项目成果

Intraoperative Robotic-Assisted Large-Area High-Speed Microscopic Imaging and Intervention

术中机器人辅助大面积高速显微成像和干预

• DOI: 10.1109/tbme.2018.2837058
• 发表时间: 2019
• 期刊: IEEE Transactions on Biomedical Engineering
• 影响因子: 4.6
• 作者: Giataganas P

Cooperative in situ microscopic scanning and simultaneous tissue surface reconstruction using a compliant robotic manipulator

使用顺从的机器人操纵器进行协作原位显微扫描和同步组织表面重建

• DOI: 10.1109/icra.2013.6631348
• 发表时间: 2013
• 作者: Giataganas P

A miniaturised robotic probe for real-time intraoperative fusion of ultrasound and endomicroscopy

用于术中超声和内窥镜实时融合的小型机器人探头

• DOI: 10.1109/icra.2015.7139343
• 发表时间: 2015
• 作者: Dwyer G

High speed, line-scanning, fiber bundle fluorescence confocal endomicroscopy for improved mosaicking.

• DOI: 10.1364/boe.6.001241
• 发表时间: 2015-04
• 期刊: Biomedical optics express
• 影响因子: 3.4
• 作者: M. Hughes;Guang-Zhong Yang