Acute effects of sweet flavoring and nicotine in e-cigarettes on brain activity during food decisions
电子烟中甜味剂和尼古丁对食物决策过程中大脑活动的急性影响
基本信息
- 批准号:10598091
- 负责人:
- 金额:$ 20.63万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-04-01 至 2025-03-31
- 项目状态:未结题
- 来源:
- 关键词:AbstinenceAcuteAmericanAppetite RegulationBehaviorBehavioralBerryBindingBody WeightBody mass indexBrainBrain regionCherry - dietaryCigaretteCigarette SmokerClinicalConsumptionCouplingCuesDatabasesDesire for foodElectronic cigaretteEnrollmentFlavoringFoodFunctional Magnetic Resonance ImagingGlucoseGoalsHomeostasisHumanHungerHypothalamic structureImageLinkMaintenanceMeasuresMedialMetabolicMetabolismNeurosciencesNicotineNicotine WithdrawalNutrientObesityOralOverweightParticipantPerfusionPersonsPlayPopulationProtocols documentationPublic HealthReportingResearchResolutionRestRoleRunningSatiationSavoryScanningSensorySignal TransductionStandardizationSweetening AgentsTaste PerceptionTestingVentral StriatumVisitVisualWeightWeight GainWeight maintenance regimenWorkarterial spin labelingattenuationbehavior measurementbiobehaviorblood oxygen level dependentcigarette smokecigarette smokingdesignelectronic cigarette useelectronic cigarette userelectronic liquidexperiencefood flavorincreased appetiteindexinginterestliquid formulationneuralneuroimagingnon-smokerpublic health interventionreceptorrecruitresponsesmoking cessationstructural imagingsweet taste perceptiontobacco flavortoolvapingyoung adult
项目摘要
PROJECT SUMMARY
Use of e-cigarettes has become widespread in young adults. One factor motivating initiation and maintenance
of e-cigarette use is its perceived value in weight management. This is especially true among those with
overweight and obesity. However, the actual effects of e-cigarette use on appetite are not well characterized.
In the proposed work we will examine the impact of two common e-liquid constituents that may be relevant: 1)
sweet flavoring, and 2) nicotine content. Through THE USC-TCORS database of active research participants,
we will enroll thirty-two young adult daily e-cigarette users with BMI in the overweight or obese range.
Participants will complete a baseline session followed by four neuroimaging test-sessions, each after overnight
fast and abstinence from any nicotine products. At each neuroimaging session, participants will complete a 30-
min vaping protocol prior to testing. The content of the e-liquid for sessions will vary according to a 2 X 2
design varying flavor (Sweet+/Sweet-) and nicotine content (Nic+/Nic-), Subsequent to vaping, participants will
undergo functional Magnetic Resonance Imaging (fMRI). During imaging participants will complete a task in
which they have the opportunity to bid real money on available food (half sweet and half savory), with the
possibility of consumption immediately following scanning (Food Bid Task). In past use of this task, we have
shown reduction in monetary bids and in MR-signal (a marker of neural activity) within brain regions linked to
appetite following oral consumption of non-nutritive sweetener (sweet taste without nutrients). Based primarily
on past work with cigarette smoke, we anticipate that nicotine will be associated with attenuation of activity
within brain regions linked to appetite during food decisions, and with reduced monetary bids. Possible effects
of sweet flavor are less clear, since both sensory-specific satiety (attenuation of appetite for similarly flavored
foods) and sensory-specific appetite (increased appetite for similarly flavored foods) have been reported when
aroma and taste is experienced without consumption. Participants will also complete a resting state scan using
Arterial Spin Labeling (ASL) to quantify any general effects of study variables on perfusion throughout the
brain. The proposed work leverages the multiple PIs expertise in e-cigarette use (Tackett), CNS regulation of
appetite (Page) and decision neuroscience (Monterosso). Findings will provide essential information for
understanding the connection between e-cigarette use and appetite.
项目摘要
电子烟的使用在年轻人中已经很普遍。促使启动和维持的一个因素
电子烟的使用是其在体重管理中的感知价值。尤其是那些有
超重和肥胖。然而,使用电子烟对食欲的实际影响并没有很好的描述。
在拟议的工作中,我们将研究可能相关的两种常见电子液体成分的影响:1)
甜味剂,和2)尼古丁含量。通过积极研究参与者的USC-TCORS数据库,
我们将招募32名BMI在超重或肥胖范围内的年轻成年日常电子烟使用者。
参与者将完成一个基线会议,然后是四个神经成像测试会议,每一个通宵后,
禁食和戒除任何尼古丁产品。在每次神经成像会议上,参与者将完成30-
最小vaping协议之前测试.会议的电子液体的内容将根据2 X 2
设计不同的口味(甜+/甜-)和尼古丁含量(Nic+/Nic-),在吸电子烟后,参与者将
进行功能性磁共振成像(fMRI)。在成像过程中,参与者将在
他们有机会对可用的食物(半甜半咸)出价真实的钱,
扫描后立即食用的可能性(食品投标任务)。在过去使用此任务时,我们已经
显示出货币出价和MR信号(神经活动的标志)的减少,
口服非营养性甜味剂后的食欲(无营养的甜味)。主要依据
根据以往对香烟烟雾的研究,我们预计尼古丁将与活动衰减有关。
在食物决策过程中与食欲相关的大脑区域内,并且减少了货币出价。可能影响
甜味的影响不太清楚,因为感官特异性饱腹感(对类似风味的食欲减弱)
食物)和感官特异性食欲(对相似风味食物的食欲增加),
香气和味道是在没有消费的情况下体验到的。参与者还将使用
动脉自旋标记(ASL),以量化研究变量对整个灌注的任何一般影响
个脑袋拟议的工作利用了多个PI在电子烟使用方面的专业知识(Tackett),
食欲(Page)和决策神经科学(Monterosso)。调查结果将提供重要信息,
了解电子烟使用与食欲之间的联系。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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John R Monterosso其他文献
John R Monterosso的其他文献
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{{ truncateString('John R Monterosso', 18)}}的其他基金
Acute effects of sweet flavoring and nicotine in e-cigarettes on brain activity during food decisions
电子烟中甜味剂和尼古丁对食物决策过程中大脑活动的急性影响
- 批准号:
10438421 - 财政年份:2022
- 资助金额:
$ 20.63万 - 项目类别:
Neuroeconomics of sugars: Glucose vs. fructose effects on reward signaling
糖的神经经济学:葡萄糖与果糖对奖励信号的影响
- 批准号:
9321514 - 财政年份:2017
- 资助金额:
$ 20.63万 - 项目类别:
Effect of anticipated delay on neural response to signal of future reward
预期延迟对未来奖励信号的神经反应的影响
- 批准号:
7658304 - 财政年份:2008
- 资助金额:
$ 20.63万 - 项目类别:
Effect of anticipated delay on neural response to signal of future reward
预期延迟对未来奖励信号的神经反应的影响
- 批准号:
7828210 - 财政年份:2008
- 资助金额:
$ 20.63万 - 项目类别:
Effect of anticipated delay on neural response to signal of future reward
预期延迟对未来奖励信号的神经反应的影响
- 批准号:
7473092 - 财政年份:2008
- 资助金额:
$ 20.63万 - 项目类别:
Neural recruitment during self-control of smoking: An fMRI paradigm
吸烟自我控制过程中的神经募集:功能磁共振成像范式
- 批准号:
7318115 - 财政年份:2007
- 资助金额:
$ 20.63万 - 项目类别:
Neural recruitment during self-control of smoking: An fMRI paradigm
吸烟自我控制过程中的神经募集:功能磁共振成像范式
- 批准号:
7487077 - 财政年份:2007
- 资助金额:
$ 20.63万 - 项目类别:
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