Acute effects of sweet flavoring and nicotine in e-cigarettes on brain activity during food decisions

电子烟中甜味剂和尼古丁对食物决策过程中大脑活动的急性影响

• 批准号: 10598091
• 负责人: John R Monterosso
• 金额: $ 20.63万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10598091
• 关键词: Abstinence; Acute; American; Appetite Regulation; Behavior; Behavioral; Berry; Binding; Body Weight; Body mass index; Brain; Brain region; Cherry - dietary; Cigarette; Cigarette Smoker; Clinical; Consumption; Coupling; Cues; Databases; Desire for food; Electronic cigarette; Enrollment; Flavoring; Food; Functional Magnetic Resonance Imaging; Glucose; Goals; Homeostasis; Human; Hunger; Hypothalamic structure; Image; Link; Maintenance; Measures; Medial; Metabolic; Metabolism; Neurosciences; Nicotine; Nicotine Withdrawal; Nutrient; Obesity; Oral; Overweight; Participant; Perfusion; Persons; Play; Population; Protocols documentation; Public Health; Reporting; Research; Resolution; Rest; Role; Running; Satiation; Savory; Scanning; Sensory; Signal Transduction; Standardization; Sweetening Agents; Taste Perception; Testing; Ventral Striatum; Visit; Visual; Weight; Weight Gain; Weight maintenance regimen; Work; arterial spin labeling; attenuation; behavior measurement; biobehavior; blood oxygen level dependent; cigarette smoke; cigarette smoking; design; electronic cigarette use; electronic cigarette user; electronic liquid; experience; food flavor; increased appetite; indexing; interest; liquid formulation; neural; neuroimaging; non-smoker; public health intervention; receptor; recruit; response; smoking cessation; structural imaging; sweet taste perception; tobacco flavor; tool; vaping; young adult

PROJECT SUMMARY Use of e-cigarettes has become widespread in young adults. One factor motivating initiation and maintenance of e-cigarette use is its perceived value in weight management. This is especially true among those with overweight and obesity. However, the actual effects of e-cigarette use on appetite are not well characterized. In the proposed work we will examine the impact of two common e-liquid constituents that may be relevant: 1) sweet flavoring, and 2) nicotine content. Through THE USC-TCORS database of active research participants, we will enroll thirty-two young adult daily e-cigarette users with BMI in the overweight or obese range. Participants will complete a baseline session followed by four neuroimaging test-sessions, each after overnight fast and abstinence from any nicotine products. At each neuroimaging session, participants will complete a 30- min vaping protocol prior to testing. The content of the e-liquid for sessions will vary according to a 2 X 2 design varying flavor (Sweet+/Sweet-) and nicotine content (Nic+/Nic-), Subsequent to vaping, participants will undergo functional Magnetic Resonance Imaging (fMRI). During imaging participants will complete a task in which they have the opportunity to bid real money on available food (half sweet and half savory), with the possibility of consumption immediately following scanning (Food Bid Task). In past use of this task, we have shown reduction in monetary bids and in MR-signal (a marker of neural activity) within brain regions linked to appetite following oral consumption of non-nutritive sweetener (sweet taste without nutrients). Based primarily on past work with cigarette smoke, we anticipate that nicotine will be associated with attenuation of activity within brain regions linked to appetite during food decisions, and with reduced monetary bids. Possible effects of sweet flavor are less clear, since both sensory-specific satiety (attenuation of appetite for similarly flavored foods) and sensory-specific appetite (increased appetite for similarly flavored foods) have been reported when aroma and taste is experienced without consumption. Participants will also complete a resting state scan using Arterial Spin Labeling (ASL) to quantify any general effects of study variables on perfusion throughout the brain. The proposed work leverages the multiple PIs expertise in e-cigarette use (Tackett), CNS regulation of appetite (Page) and decision neuroscience (Monterosso). Findings will provide essential information for understanding the connection between e-cigarette use and appetite.

项目摘要 电子烟的使用在年轻人中已普遍存在。激励启动和维护的一个因素 电子烟的使用是其在体重管理中的感知价值。在有 超重和肥胖。但是，电子烟的实际影响对食欲的影响尚未得到很好的特征。 在拟议的工作中，我们将研究可能相关的两个常见的电子液体成分的影响：1） 甜味，2）尼古丁含量。通过主动研究参与者的USC-TCORS数据库 我们将在超重或肥胖范围内注册32名年轻人每日电子烟使用者。 参与者将完成一个基线会议，然后完成四个神经影像学测试课程，每次过夜 任何尼古丁产品的快速和禁欲。在每个神经影像学会议上，参与者将完成30- 测试之前的最小蒸发协议。会话的电子液体的内容会根据2 x 2而有所不同 设计不同的风味（甜+/甜）和尼古丁含量（NIC+/NIC-），参与者将参与者 进行功能磁共振成像（fMRI）。在成像期间，参与者将完成一项任务 他们有机会在可用食物（一半甜和一半的咸味）上竞标真钱， 扫描后立即消费的可能性（食品出价任务）。在过去使用此任务时，我们有 显示了与大脑区域内的MR-Signal（神经活动标记）的货币投标减少 口服非营养甜味剂（不含营养的甜味）之后食欲。主要基于 在过去的香烟烟雾中，我们预计尼古丁会与活动的衰减有关 在食物决策过程中与食欲相关的大脑区域内，并减少了货币出价。可能的影响 甜味不太清楚，因为这两个特定于感官的饱腹感） 据报道，食物）和特定于感官的食欲（对类似调味的食物的食欲增加） 香气和味道是无需消费而体验的。参与者还将使用 动脉自旋标记（ASL），以量化研究变量对灌注的任何一般影响 脑。拟议的工作利用了电子烟使用中的多个PIS专业知识（Tackett），CNS的监管 食欲（PAGE）和决策神经科学（Monterosso）。调查结果将为 了解电子烟的使用和食欲之间的联系。