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ULTRASONIC CONTRAST BLOOD FLOWMETRY

超声波对比血流计

基本信息

批准号：
3366199
负责人：
K KIRK SHUNG
金额：
$ 7.14万
依托单位：
PENNSYLVANIA STATE UNIVERSITY, THE
依托单位国家：
美国
项目类别：
财政年份：
1991
资助国家：
美国
起止时间：
1991-08-01 至 1994-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3366199
关键词：
animal tissue contrast media indicator dilution test method development online computer pulmonary circulation ultrasound blood flow measurement

项目摘要

Great strides have recently been made in the development of nontoxic transpulmonary ultrasonic contrast agents and time domain blood flowmetry. The proposed research is a marriage of these two new developments. Time domain blood flow estimation although has been proven to be feasible and to have several advantages over ultrasonic Doppler methods suffers from low signal to noise ratio because the signal backscattered from blood is extremely weak, By using ultrasonic contrast agents, this problem can be circumvented. Preliminary results have demonstrated the potential of ultrasonic contrast blood flowmetry. In this research, the following approaches on time domain blood flowmetry will be pursued in vitro in conjunction with the utilization of ultrasonic contrast media in a mock flow loop. (1) Mean blood flow velocity will be estimated from a measurement of the time course of the variation in the ultrasonic attenuation of blood following the bolus injection of a contrast agent based upon the indicator dilution principle. (2) Mean velocity and velocity profile in a vessel will be determined using an optical correlator from recorded video ultrasonic images following bolus injection of a contrast agent. (3) Flow field in 2-D will be determined using a two-probe arrangement from cross-correlation of the RF signals detected by these two probes. The proposed work is exploratory in nature and intends primarily to show the feasibility of these approaches in a fundamental way. Once the feasibility of an approach is established, research in a larger scale involving animals will ensue.

无毒食品的开发最近取得了长足的进步。经肺超声造影剂和时域血流量测定。这项拟议的研究是这两项新发展的结合。时间领域血流估计，尽管已被证明是可行的，并与超声多普勒法相比有几个优点信噪比，因为血液的后向散射信号非常弱，通过使用超声造影剂，这个问题可以绕过了。初步结果表明，超声造影剂血流量测定仪。在这项研究中，以下是时间域血流测量的方法将在#年进行体外研究超声造影剂在模拟手术中的应用流动环路。(1)平均血流速度将由超声波变化时程的测量注射造影剂后血液的衰减基于指示剂稀释原理。(2)平均速度和将使用光学相关器来确定容器中的速度分布从记录的视频超声图像后，团注造影剂。(3)用双探头测量二维内的流场根据由这两个设备检测到的RF信号的互相关来排列探测器。建议的工作是探索性的，主要是为了展示从根本上论证了这些方法的可行性。一旦建立了一种可行的方法，在更大范围内进行研究动物的参与也会随之而来。