SensoPellet: A new tool to investigate signalling and motility in the lower digestive tract

SensoPellet：研究下消化道信号传导和运动的新工具

• 批准号: EP/J000175/1
• 负责人: Bhavik Patel
• 金额: $ 12.61万
• 依托单位: University of Brighton
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FJ000175%2F1
• 关键词: SensoPellet; new; tool; investigate; signalling

Chronic constipation and faecal incontinence are prevalent in the elderly and often lead to social isolation. Little is known regarding why these conditions occur with age; however they have been classified as functional bowel disorders. Signalling molecules such as serotonin regulate the motility of the bowel, and therefore investigating alterations in these signalling molecules may help our understanding of these disorders. In this proposed project we aim to develop a new medical device, known as the SensoPellet, which is a sensor based device moulded into the shape of a faecal pellet. This device will be used to understand the process of normal defecation. The device will consist of carbon composite electrodes encased in a cavity moulded into the shape of a faecal pellet. This device will be characterised for its suitability for conducting stable biological recordings in colonic tissue. Biological recordings will allow the means to simultaneously monitor serotonin levels and image the motion of the pellet to understand the process of terminal bowel motility. The ability of the device to help us elucidate the process of normal defecation is important to understand what changes occur during the onset of age related disorders or how colonic motility is altered by various therapeutic agents utilised at present.

慢性便秘和大便失禁在老年人中很普遍，往往导致社会孤立。关于为什么这些情况会随着年龄的增长而发生，人们知之甚少；然而，它们被归类为功能性肠道疾病。像血清素这样的信号分子调节肠道的运动，因此研究这些信号分子的变化可能有助于我们理解这些疾病。在这个提议的项目中，我们的目标是开发一种新的医疗设备，称为SensoPellet，这是一种基于传感器的设备，被塑造成粪便颗粒的形状。这个装置将被用来了解正常排便的过程。该装置将由碳复合电极组成，电极被包裹在一个模塑成粪便颗粒形状的腔中。该设备的特点是适合在结肠组织中进行稳定的生物记录。生物记录将允许同时监测血清素水平和成像颗粒的运动，以了解终端肠蠕动的过程。该装置帮助我们阐明正常排便过程的能力对于理解年龄相关疾病发病期间发生的变化或目前使用的各种治疗药物如何改变结肠运动是很重要的。

项目成果

Compressed multiwall carbon nanotube composite electrodes provide enhanced electroanalytical performance for determination of serotonin

• DOI: 10.1016/j.electacta.2014.06.050
• 发表时间: 2014-08-20
• 期刊: ELECTROCHIMICA ACTA
• 影响因子: 6.6
• 作者: Fagan-Murphy, Aidan;Patel, Bhavik Anil
• 通讯作者: Patel, Bhavik Anil

Detection of clinically important cations by a pillar[5]arene-modified electrochemical sensor

通过柱[5]芳烃修饰的电化学传感器检测临床重要的阳离子

• 期刊: Chemical Sensors
• 作者: Bhavik Patel (Author)

Electrochemical fecal pellet sensor for simultaneous real-time ex vivo detection of colonic serotonin signalling and motility.

• DOI: 10.1038/srep23442
• 发表时间: 2016-03-22
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Morris R;Fagan-Murphy A;MacEachern SJ;Covill D;Patel BA
• 通讯作者: Patel BA

Inhibiting Inducible Nitric Oxide Synthase in Enteric Glia Restores Electrogenic Ion Transport in Mice With Colitis.

• DOI: 10.1053/j.gastro.2015.04.007
• 发表时间: 2015-08
• 期刊: Gastroenterology
• 影响因子: 29.4
• 作者: MacEachern SJ;Patel BA;Keenan CM;Dicay M;Chapman K;McCafferty DM;Savidge TC;Beck PL;MacNaughton WK;Sharkey KA
• 通讯作者: Sharkey KA

Buckycolumn electrodes: a practical and improved alternative to conventional materials utilised for biological electrochemical monitoring.

• DOI: 10.1039/c3tb20802h
• 发表时间: 2013-08
• 期刊: Journal of materials chemistry. B
• 作者: Aidan Fagan-Murphy;R. Whitby;B. Patel