AUDITORY EVOKED BRAIN POTENTIALS IN NEUROLOGICAL DISEASE

神经系统疾病中听觉诱发的大脑电位

• 批准号: 3394646
• 负责人: Arnold Starr
• 金额: $ 34.5万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-09-01 至 1987-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3394646
• 关键词: aphasia; auditory discrimination; auditory feedback; auditory stimulus; brain disorders; brain electrical activity; brain stem; cognition disorders; coma; electrophysiology; evoked potentials; experimental brain lesion; hearing tests; human subject; language disorders; nervous system disorder diagnosis; neural information processing; neurophysiology; neuropsychological tests; stimulus /response

We plan to study auditory evoked potentials in both clinical neurological disorders and animal experiments to define neural mechanisms of the generation of these potentials. In particular, we will study in experimental animals the role of pontine auditory structures in generating auditory brainstem components using discrete lesion methods. The generation of middle-latency, long-latency, and endogenous components will be examined using electrical recording and lesion methods in monkeys engaged in an auditory discrimination task. The application of auditory evoked potentials to patients with neurological disorders will be for 1) longlatency and endogenous components during the recovery from coma; 2) the effects of task complexity on endogenous components in dementing illnesses and 3) endogenous components during the catagorization of words in patients with aphasia.

我们计划研究临床神经学中的听觉诱发电位 疾病和动物实验来定义神经机制 这些潜力的产生。 特别是，我们将学习 实验动物脑桥听觉结构在生成中的作用 使用离散损伤方法的听觉脑干成分。 这 中潜伏期、长潜伏期和内源性成分的产生将 使用电记录和损伤方法对猴子进行检查 从事听觉辨别任务。 听觉的应用 神经系统疾病患者的诱发电位将为 1) 昏迷恢复期间的长潜伏期和内源性成分； 2） 任务复杂性对痴呆症内源性成分的影响 3）患者词语分类过程中的内源成分 患有失语症。