MOTOR CONTROL IN CHRONIC FATIGUE SYNDROME

描述：（改编自研究者摘要）先前研究的结果 格兰特期间使用电生理记录支持的假设 CFS患者有中枢运动控制障碍 此外，委员会还认为， 其他人最近使用经颅磁刺激的研究也指出， 中枢听觉通路的异常 中的患者 我们的研究表明，在需要快速反应的任务中， 以及伴随运动反应准备的大脑活动受损。 经颅磁刺激已经证明， CFS中的运动皮层输出伴随持续的运动活动。 我们 拟议的新项目的目标是确定改变的时间进程， CFS患者运动诱导一段时间前后的运动皮质功能 疲劳 CFS异常的特异性将通过 与一组临床抑郁症患者进行比较。 的方法 的研究利用慢脑电位的神经生理学记录 伴随着几种不同类型的响应准备， 经颅磁刺激运动皮层，以测量 减少中央电机驱动。

DESCRIPTION: (Adapted from Investigator's Abstract) Results from the prior grant period using electrophysiological recordings support the hypothesis that patients with CFS have a disorder of central motor control. Moreover, recent studies by others using transcranial magnetic stimulation also point to the central auditory pathway as being abnormal in CFS. The patients in our studies showed slowed reaction times in tasks requiring rapid responses and impaired brain activities accompanying motor response preparation. Transcranial magnetic stimulation has demonstrated a premature reduction of motor cortical output in CFS accompanying sustained motor activities. Our goals in the proposed new project are to define the time course of altered motor cortical function in CFS before and after a period of exercise-induced fatigue. The specificity of the abnormalities for CFS will be tested by comparison with a group of patients with clinical depression. The methods of study utilize neurophysiological recordings of slow brain potentials accompanying several different types of response preparation and transcranial magnetic stimulation of motor cortex to measure the extent of reduction of central motor drive.