Core--Clinical

描述（改编自应用程序）：临床核心功能， 维持至少400名志愿者患者（包括 阿尔茨海默病、相关痴呆和唐氏综合征患者， 痴呆）和150名非痴呆的老年对照（年龄75岁及以上）， 每年评估，愿意参与研究，并有， 同意进行尸检另外148名75岁以下的非痴呆对照 年龄每两年评估一次。到下一个更新期， 建议招募的病人包括那些患有轻度 阶段的痴呆症和目前与局灶性认知障碍，以满足这两个 临床和神经病理学研究的需要。研究人员建议 招募更多的控制人员，以满足对控制大脑日益增长的需求 神经病理学中心的组织所有数据均来自年度临床评价 和神经病理学评估，在适当的情况下，由 管理核心和存储在阿尔茨海默氏症中心数据库，包括 可供使用的详细的纵向行为和神经病理学数据 各种研究项目。临床和神经病理学核心是统一的 通过这个数据管理系统，促进研究之间的联系， 临床和基础科学。临床核心也将继续培养 改进诊断方法的新方法， 评估种族多样性，非英语学科的技术。 通过建立在学习和研究已经建立的声誉， 记忆，核心也将促进大脑系统和电路的研究 并将这些与特定的临床表现，脑成像， 神经病理学测量。临床核心为34名患者提供了资源 在上一个供资周期， 报纸核心的首要任务是确保病人的隐私， 无论何时，研究项目都将纳入潜在的治疗方法， 可能

DESCRIPTION (Adapted from the application): The Clinical Core functions to maintain an active cohort of at least 400 volunteer patients (including Alzheimer's disease, related dementias, and individuals with Down syndrome and dementia) and 150 non-demented, elderly controls (age 75 and up) who are evaluated annually, are willing to participate in research, and have, consented to autopsy. The additional 148 non-demented controls under 75 years of age are evaluated every two years. By the next renewal period the recruitment of patients is proposed to include those who are in the mild stages of dementia and present with focal cognitive impairments to meet both clinical and neuropathological research needs. The investigators propose to recruit additional controls to address the increasing need for control brain tissue by the Neuropathology Core. All data from annual clinical evaluations and the neuropathological evaluation, when appropriate, are managed by the Administrative Core and stored in the Alzheimer's Center database and include detailed, longitudinal behavioral and neuropathological data available for use in various research projects. The Clinical and Neuropathology Cores are united via this data management system that facilitates research links between clinical and basic sciences. The Clinical Core will also continue to foster novel approaches to improve diagnostic methods and continue developing techniques for evaluating ethnically diverse, non-English speaking subjects. By building upon the already established reputation in studies of leaning and memory, the Core will also facilitate the study of brain systems and circuits and relate these to specific clinical presentations, brain imaging, and neuropathological measures. The Clinical Core provided resources for 34 investigators during the last funding cycle and generated over 74 published papers. The Core's overriding priority is to ensure patient privacy and well being, and research projects will incorporate potential therapies whenever possible.