NEUROBIOLOGICAL STUDY OF VOCALIZATION

发声的神经生物学研究

• 批准号: 3386825
• 负责人: MEI-FANG CHENG
• 金额: $ 7.68万
• 依托单位: RUTGERS THE STATE UNIV OF NJ NEWARK
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-08-01 至 1993-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3386825
• 关键词: Aves; animal communication behavior; central neural pathway /tract; electron microscopy; enkephalins; hormone regulation /control mechanism; immunocytochemistry; immunofluorescence technique; mesencephalon; neuroendocrine system; radioimmunoassay; radiotracer; sex behavior; vocalization

The long term objective of this project is to determine the biological significance of the "non-communicative" function of vocalization and characterize the underlying physiological mechanisms. Although vocalization has traditionally been viewed as a mean of communication, recent evidence from my laboratory strongly indicates that communication also function in an integral physiological capacity. Birdsong, especially in passerine species, has long been a favored research system. The issue of learning in development of song and adaptive significance of acoustic communication are among the problems which have been addressed. The primary question of the mechanism by which the male song may influence the female's endocrine response, culminating in egg- laying, has not been studied. However, this issue has been subject of intensive study of non-songbird system. Recent findings in the study of the female ringdove (Streptopelia risoria) reproductive system has revealed an interesting dimension of vocalization which has received little attention. We have found that a bird's vocalization alters its endocrine state. What neural pathways mediate this endocrine response? Can we demonstrate this basic finding in morphological terms? Are there different circuities involved in endocrine consequence of courtship vs other vocalization such as alarm calls? In this application, I will determine and characterize the chemical features of the neural pathways which mediate the conversion of vocalization into endocrine response. In other words, we intend to demonstrate that an increased luteinizing hormone-releasing hormone (LHRH) release can be traced to neuronal activity in the vocal control nuclei associated with the performance of female nest calls. The proposed studies will add useful information about how acoustic inputs, especially those generated from the individual's own vocalization affect endocrine state and hence the well-being of the individual.

该项目的长期目标是确定生物学 发声的“非交流”功能的重要性和 表征基本的生理机制。 尽管传统上被视为发声是 沟通，我的实验室的最新证据强烈表明 交流也以整体生理能力发挥作用。 鸟鸣，尤其是在passerine物种中，长期以来一直是一项偏爱的研究 系统。 歌曲发展和自​​适应的学习问题 声学交流的重要性是有 已解决。 男性的主要问题 歌曲可能会影响女性内分泌反应，最终在卵中 - 铺设，尚未研究。 但是，这个问题一直是 非养鸟系统的密集研究。 研究的最新发现 雌性铃声（链球菌）生殖系统已揭示 一个有趣的发声维度，几乎没有收到 注意力。 我们发现鸟的发声改变了内分泌 状态。 哪些神经途径介导这种内分泌反应？ 我们可以吗？ 用形态学的角度展示这一基本发现？ 有不同的地方 求爱后果与其他分泌后果有关的电路与其他 发声，例如警报电话？ 在此应用程序中，我将确定 并表征介导的神经途径的化学特征 发声转换为内分泌反应。 换句话说，我们 打算证明黄体生成激素释放增加 激素（LHRH）释放可以追溯到声带中的神经元活动 控制核与女性巢呼叫的性能相关。 拟议的研究将添加有关声学输入如何， 特别是那些由个人自身发声产生的影响 内分泌状态以及个人的福祉。