FUNCTIONAL RECOVERY--NEUROGENESIS AND SOCIAL ENVIRONMENT

功能恢复--神经发生和社会环境

• 批准号: 2442043
• 负责人: MEI-FANG CHENG
• 金额: $ 17.41万
• 依托单位: RUTGERS THE STATE UNIV OF NJ NEWARK
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2442043
• 关键词: Aves; RNA binding protein; behavioral /social science research tag; biomarker; brain injury; estradiol; experimental brain lesion; functional ability; gender difference; hormone regulation /control mechanism; hypothalamus; immunocytochemistry; neural plasticity; neurogenesis; phenotype; progesterone; sex behavior; socioenvironment; testosterone

DESCRIPTION (adapted from applicant's abstract): The long term objective of this proposal is to investigate the underlying mechanisms of brain repair. A normal brain receives stimuli and information and responds to its environment. A damaged brain attempts the same process, but has the added task of reorganization through interactions between neurons and the immediate and external environments. Post-traumatic environmental conditions, both physical and social, can enhance or impede the brain repair process. In this proposal, experiments are proposed to explore and identify aspects of social properties that facilitate brain recovery and the role of neurogenesis in the improvement of brain function. Specifically, discrete lesions in the hypothalamus will be used to experimentally render male ring doves unable to perform courtship behaviors when initially introduced to a female. It has previously been shown that housing a male who has lesion damage with a mature female will facilitate the full recovery of courtship behavior. In experiments designed to determine which environmental factors may play a role in the reinstatement of courtship behavior, brain damaged males will be exposed to a variety of social conditions. Additionally, preliminary studies of adult ring doves strongly suggest that brain lesions dramatically increase ventricular mitotic activity. With the use of the Hu protein (a family of neuronal RNA-binding proteins) as an early marker of neuronal phenotypic differentiation, the PI plans to demonstrate that neurogenesis is promoted by brain lesions and to explicate the role of neurogenesis in brain repair. Despite a recent surge in the study of brain repair, the possible role played by neurogenesis in the recovery of function have been virtually ignored. Results of the proposed studies will address this question directly and may lead to a promising new direction for the investigation of mechanisms of brain repair after injury.

描述(改编自申请人的摘要)：长期目标 这项提议是为了研究大脑修复的潜在机制。 正常的大脑接收刺激和信息，并对其作出反应 环境。受损的大脑尝试着同样的过程，但增加了 通过神经元和神经元之间的相互作用进行重组的任务 直接环境和外部环境。创伤后环境 身体状况和社会状况都会促进或阻碍大脑修复 进程。 在这项建议中，提出了实验来探索和识别方面 促进大脑恢复的社会属性以及 神经发生在改善脑功能中的作用。具体地说，离散的 下丘脑的损伤将被用来实验性地呈现男性环 鸽子在最初被引入时不能进行求偶行为 女性。此前已有研究表明，收容有皮损的男性 对成熟雌性的伤害将促进求爱的完全恢复 行为。在旨在确定哪些环境因素的实验中 可能在恢复求爱行为中起作用，大脑受损 男性将暴露在各种社会条件下。另外， 对成年环鸽的初步研究强烈表明，大脑损伤 显著增加了有丝分裂的活跃度。通过使用HU 蛋白质(神经性RNA结合蛋白家族)作为早期标志物 神经元表型分化，PI计划证明 通过脑损伤促进神经发生，并解释 脑修复中的神经发生。 尽管最近对大脑修复的研究激增，但它可能扮演的角色 神经再生在功能恢复中所起的作用 已被忽略。拟议研究的结果将解决这个问题。 并可能导致对……的调查 脑损伤后修复的机制。