FUNCTIONAL RECOVERY--NEUROGENESIS AND SOCIAL ENVIRONMENT

功能恢复--神经发生和社会环境

• 批准号: 2442043
• 负责人: MEI-FANG CHENG
• 金额: $ 17.41万
• 依托单位: RUTGERS THE STATE UNIV OF NJ NEWARK
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2442043
• 关键词: Aves; RNA binding protein; behavioral /social science research tag; biomarker; brain injury; estradiol; experimental brain lesion; functional ability; gender difference; hormone regulation /control mechanism; hypothalamus; immunocytochemistry; neural plasticity; neurogenesis; phenotype; progesterone; sex behavior; socioenvironment; testosterone

DESCRIPTION (adapted from applicant's abstract): The long term objective of this proposal is to investigate the underlying mechanisms of brain repair. A normal brain receives stimuli and information and responds to its environment. A damaged brain attempts the same process, but has the added task of reorganization through interactions between neurons and the immediate and external environments. Post-traumatic environmental conditions, both physical and social, can enhance or impede the brain repair process. In this proposal, experiments are proposed to explore and identify aspects of social properties that facilitate brain recovery and the role of neurogenesis in the improvement of brain function. Specifically, discrete lesions in the hypothalamus will be used to experimentally render male ring doves unable to perform courtship behaviors when initially introduced to a female. It has previously been shown that housing a male who has lesion damage with a mature female will facilitate the full recovery of courtship behavior. In experiments designed to determine which environmental factors may play a role in the reinstatement of courtship behavior, brain damaged males will be exposed to a variety of social conditions. Additionally, preliminary studies of adult ring doves strongly suggest that brain lesions dramatically increase ventricular mitotic activity. With the use of the Hu protein (a family of neuronal RNA-binding proteins) as an early marker of neuronal phenotypic differentiation, the PI plans to demonstrate that neurogenesis is promoted by brain lesions and to explicate the role of neurogenesis in brain repair. Despite a recent surge in the study of brain repair, the possible role played by neurogenesis in the recovery of function have been virtually ignored. Results of the proposed studies will address this question directly and may lead to a promising new direction for the investigation of mechanisms of brain repair after injury.

描述（改编自申请人的摘要）： 本研究旨在探讨脑修复的潜在机制。 正常的大脑接受刺激和信息，并对其做出反应。 环境 一个受损的大脑尝试同样的过程，但有额外的 通过神经元和神经元之间的相互作用进行重组 直接和外部环境。 创伤后环境 身体和社会条件可以增强或阻碍大脑修复， 过程 在这个提议中，提出了实验来探索和识别方面 促进大脑恢复的社会属性以及 神经发生在改善脑功能中的作用。 具体来说，离散 下丘脑的损伤将被用来实验性地使男性环 鸽子不能执行求爱行为时，最初介绍给一个 女性 先前已经表明，将患有病变的男性 与成熟雌性的伤害将促进求爱的完全恢复 行为 在旨在确定哪些环境因素 可能在求爱行为的恢复中发挥作用，大脑受损 男性会接触到各种各样的社会环境。 此外，本发明还 对成年环鸽的初步研究强烈表明， 显著增加心室有丝分裂活动。 随着胡的使用 蛋白质（神经元RNA结合蛋白家族）作为早期标志物， 神经元表型分化，PI计划证明， 神经发生是由脑损伤促进的， 脑修复中的神经发生 尽管最近对大脑修复的研究激增， 神经发生在功能恢复中所起的作用几乎已经被 忽视 拟议研究的结果将解决这一问题 直接，并可能导致一个有前途的新方向的调查， 脑损伤后的修复机制。