UNDERNUTRITION VULNERABLE BRAIN SUBCELLULAR MEMBRANES

营养不良导致大脑亚细胞膜脆弱

• 批准号: 3395327
• 负责人: RICHARD C WIGGINS
• 金额: $ 6.52万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-01-01 至 1993-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3395327
• 关键词: animal developmental psychology; brain metabolism; laboratory rat; membrane reconstitution /synthesis; microsomes; mitochondria; myelin; neurochemistry; neurogenesis; neurotransmitter receptor; nutrition related tag; radionuclide double label; starvation; synaptosomes; thin layer chromatography; tritium

Various affects of postnatal undernutrition are being investigated using developing rats as an experimental model. Studies are largely confined to the central nervous system. Neurochemical investigations include effects on synthesis of myelin as well as on the development of neurotransmitter receptor binding systems. Morphological studies include the cellular basis of nutrition related hypomyelination. Neurophysiologic correlates include effects of undernutrition on maturation of the photic evoked responses in the retina (electroretinogram), the optic tract, lateral geniculate bodies, and the visul cortes.

目前正在调查出生后营养不良的各种影响。 发展大鼠作为实验模型。研究主要局限于 中枢神经系统。神经化学研究包括对 髓鞘合成及其对神经递质受体发育的影响 绑定系统。形态研究包括营养的细胞基础 相关的髓鞘过少。神经生理学相关因素包括 营养不良对视网膜光诱发反应成熟的影响 (视网膜电信号)、视束、外侧膝状体和视觉 科特斯。