UNDERNUTRITION VULNERABLE BRAIN SUBCELLULAR MEMBRANES
UNDERNUTRITION VULNERABLE BRAIN SUBCELLULAR MEMBRANES
批准号:
2262573
负责人:
RICHARD C WIGGINS
金额:
$12.37万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1989
资助国家:
美国
项目状态:
已结题
起止时间:
1989-01-01 至 1995-06-30
关键词:
animal developmental psychology brain metabolism carbon laboratory rat membrane reconstitution /synthesis microsomes mitochondria myelin neurochemistry neurogenesis neurotransmitter receptor nutrition related tag physical separation radionuclide double label radionuclides starvation synaptosomes thin layer chromatography tritium
中文摘要
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英文摘要
Various affects of postnatal undernutrition are being investigated using
developing rats as an experimental model. Studies are largely confined to the
central nervous system. Neurochemical investigations include effects on
synthesis of myelin as well as on the development of neurotransmitter receptor
binding systems. Morphological studies include the cellular basis of nutrition
related hypomyelination. Neurophysiologic correlates include effects of
undernutrition on maturation of the photic evoked responses in the retina
(electroretinogram), the optic tract, lateral geniculate bodies, and the visul
cortes.
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Glucocorticoid-induced upregulation of proteolipid protein and myelin-associated glycoprotein genes in C6 cells.
糖皮质激素诱导 C6 细胞中蛋白脂质蛋白和髓磷脂相关糖蛋白基因的上调。
DOI:
10.1002/jnr.490370206
发表时间:
1994
期刊:
Journal of neuroscience research
影响因子:
4.2
作者:
[Zhu,W, Wiggins,RC, Konat,GW]
通讯作者:
Konat,GW
Restraint stress during late pregnancy in rats elicits early hypermyelination in the offspring.
大鼠妊娠后期的束缚应激会引起后代早期髓鞘过度增生。
DOI:
10.1007/bf01001781
发表时间:
1986
期刊:
Metabolic brain disease
影响因子:
3.6
作者:
[Wiggins,RC, Gottesfeld,Z]
通讯作者:
Gottesfeld,Z
The corpus callosum during postnatal undernourishment and recovery: a morphometric analysis of myelin and axon relationships.
产后营养不良和恢复期间的胼胝体:髓磷脂和轴突关系的形态测量分析。
DOI:
10.1016/0006-8993(85)91321-6
发表时间:
1985
期刊:
Brain research
影响因子:
2.9
作者:
[Wiggins,RC, Bissell,AC, Durham,L, Samorajski,T]
通讯作者:
Samorajski,T
How much undernourishment is required to retard brain myelin development.
需要多少营养不良才能阻碍大脑髓磷脂的发育。
DOI:
10.1016/0197-0186(92)90157-m
发表时间:
1992
期刊:
Neurochemistry international
影响因子:
4.2
作者:
[Royland,J, Klinkhachorn,P, Konat,G, Wiggins,RC]
通讯作者:
Wiggins,RC
Myelination of the rat optic nerve during postnatal undernourishment and recovery: a morphometric analysis.
出生后营养不良和恢复期间大鼠视神经的髓鞘形成:形态测量分析。
DOI:
10.1016/0006-8993(84)91065-5
发表时间:
1984
期刊:
Brain research
影响因子:
2.9
作者:
[Wiggins,RC, Fuller,GN, Brizzee,L, Bissel,AC, Samorajski,T]
通讯作者:
Samorajski,T
共 44 条
UNDERNUTRITION VULNERABLE BRAIN SUBCELLULAR MEMBRANES
-
批准号:3395328
-
项目类别:
-
资助金额:$11.41万
-
财政年份:1989
-
负责人:RICHARD C WIGGINS
-
依托单位:
UNDERNUTRITION VULNERABLE BRAIN SUBCELLULAR MEMBRANES
-
批准号:3395330
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项目类别:
-
资助金额:$7.39万
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财政年份:1989
-
负责人:RICHARD C WIGGINS
-
依托单位:
UNDERNUTRITION VULNERABLE BRAIN SUBCELLULAR MEMBRANES
-
批准号:3395329
-
项目类别:
-
资助金额:$11.81万
-
财政年份:1989
-
负责人:RICHARD C WIGGINS
-
依托单位:
UNDERNUTRITION VULNERABLE BRAIN SUBCELLULAR MEMBRANES
-
批准号:3395327
-
项目类别:
-
资助金额:$6.52万
-
财政年份:1989
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负责人:RICHARD C WIGGINS
-
依托单位:
DRUG INTERACTIONS WITH DEVELOPING MYELIN SYSTEMS
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批准号:3209089
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项目类别:
-
资助金额:$7.47万
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财政年份:1986
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负责人:RICHARD C WIGGINS
-
依托单位:
DRUG INTERACTIONS WITH DEVELOPING MYELIN SYSTEMS
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批准号:3209091
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项目类别:
-
资助金额:$8.94万
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财政年份:1986
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负责人:RICHARD C WIGGINS
-
依托单位:
DRUG INTERACTIONS WITH DEVELOPING MYELIN SYSTEMS
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批准号:3209092
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项目类别:
-
资助金额:$1.15万
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财政年份:1986
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负责人:RICHARD C WIGGINS
-
依托单位:
DRUG INTERACTIONS WITH DEVELOPING MYELIN SYSTEMS
-
批准号:3209093
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项目类别:
-
资助金额:$7.98万
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财政年份:1986
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负责人:RICHARD C WIGGINS
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依托单位:
STARVATION-VULNERABLE BRAIN SUBCELLULAR MEMBRANES
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批准号:3395326
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项目类别:
-
资助金额:$7.58万
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财政年份:1978
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负责人:RICHARD C WIGGINS
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依托单位:
海外基金