UNDERNUTRITION VULNERABLE BRAIN SUBCELLULAR MEMBRANES

营养不良导致大脑亚细胞膜脆弱

• 批准号: 2262573
• 负责人: RICHARD C WIGGINS
• 金额: $ 12.37万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-01-01 至 1995-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2262573
• 关键词: animal developmental psychology; brain metabolism; carbon; laboratory rat; membrane reconstitution /synthesis; microsomes; mitochondria; myelin; neurochemistry; neurogenesis; neurotransmitter receptor; nutrition related tag; physical separation; radionuclide double label; radionuclides; starvation; synaptosomes; thin layer chromatography; tritium

Various affects of postnatal undernutrition are being investigated using developing rats as an experimental model. Studies are largely confined to the central nervous system. Neurochemical investigations include effects on synthesis of myelin as well as on the development of neurotransmitter receptor binding systems. Morphological studies include the cellular basis of nutrition related hypomyelination. Neurophysiologic correlates include effects of undernutrition on maturation of the photic evoked responses in the retina (electroretinogram), the optic tract, lateral geniculate bodies, and the visul cortes.

产后营养不良的各种影响正在调查使用

项目成果

Glucocorticoid-induced upregulation of proteolipid protein and myelin-associated glycoprotein genes in C6 cells.

糖皮质激素诱导 C6 细胞中蛋白脂质蛋白和髓磷脂相关糖蛋白基因的上调。

• DOI: 10.1002/jnr.490370206
• 发表时间: 1994
• 期刊: Journal of neuroscience research
• 影响因子: 4.2
• 作者: Zhu,W;Wiggins,RC;Konat,GW
• 通讯作者: Konat,GW

Restraint stress during late pregnancy in rats elicits early hypermyelination in the offspring.

大鼠妊娠后期的束缚应激会引起后代早期髓鞘过度增生。

• DOI: 10.1007/bf01001781
• 发表时间: 1986
• 期刊: Metabolic brain disease
• 影响因子: 3.6
• 作者: Wiggins,RC;Gottesfeld,Z
• 通讯作者: Gottesfeld,Z

The corpus callosum during postnatal undernourishment and recovery: a morphometric analysis of myelin and axon relationships.

产后营养不良和恢复期间的胼胝体：髓磷脂和轴突关系的形态测量分析。

• DOI: 10.1016/0006-8993(85)91321-6
• 发表时间: 1985
• 期刊: Brain research
• 影响因子: 2.9
• 作者: Wiggins,RC;Bissell,AC;Durham,L;Samorajski,T
• 通讯作者: Samorajski,T

How much undernourishment is required to retard brain myelin development.

需要多少营养不良才能阻碍大脑髓磷脂的发育。

• DOI: 10.1016/0197-0186(92)90157-m
• 发表时间: 1992
• 期刊: Neurochemistry international
• 影响因子: 4.2
• 作者: Royland,J;Klinkhachorn,P;Konat,G;Wiggins,RC
• 通讯作者: Wiggins,RC

Myelination of the rat optic nerve during postnatal undernourishment and recovery: a morphometric analysis.

出生后营养不良和恢复期间大鼠视神经的髓鞘形成：形态测量分析。

• DOI: 10.1016/0006-8993(84)91065-5
• 发表时间: 1984
• 期刊: Brain research
• 影响因子: 2.9
• 作者: Wiggins,RC;Fuller,GN;Brizzee,L;Bissel,AC;Samorajski,T
• 通讯作者: Samorajski,T